ArticleThe AAPS journal2011
Novel molecular targets of Azadirachta indica associated with inhibition of tumor growth in prostate cancer.
Article in The AAPS journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Potential ofBioMed research international · 2022Pooled it
- A comprehensive review ofBiochemistry and biophysics reports · 2026Review
- Marine trichodermamide B inhibits prostate cancer progression via catalase inhibition-induced apoptosis.Cell communication and signaling : CCS · 2026Article
- The pleiotropic anti-cancer, antiviral, and anti-neuro-immunomodulatory role of methanolic neem bark extract.Journal of natural medicines · 2025Review
- Therapeutic potential of targeting AKR1C2 in the treatment of prostate cancer.Molecular biology reports · 2024Review
- Exploring the therapeutic potential of Neem (Annals of translational medicine · 2022Review
- Characterization and application of dried neem leaf powder as a bio-additive for salt less animal skin preservation for tanneries.Environmental science and pollution research international · 2022Article
- A Review on Curcumin-Loaded Electrospun Nanofibers and their Application in Modern Medicine.JOM (Warrendale, Pa. : 1989) · 2022Review
- Review
- The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19).International journal of molecular sciences · 2020Review
- The Highly Pure Neem Leaf Extract, SCNE, Inhibits Tumorigenesis in Oral Squamous Cell Carcinoma via Disruption of Pro-tumor Inflammatory Cytokines and Cell Signaling.Frontiers in oncology · 2019Article
- Neem Seed Oil Induces Apoptosis in MCF-7 and MDA MB-231 Human Breast Cancer CellsAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Solanum Incanum Extract Downregulates Aldehyde Dehydrogenase 1-Mediated Stemness and Inhibits Tumor Formation in Ovarian Cancer Cells.Journal of Cancer · 2015Article
- Antibacterial activity of neem nanoemulsion and its toxicity assessment on human lymphocytes in vitro.International journal of nanomedicine · 2015Article
- Neem components as potential agents for cancer prevention and treatment.Biochimica et biophysica acta · 2014Review
- Preclinical evaluation of the supercritical extract of azadirachta indica (neem) leaves in vitro and in vivo on inhibition of prostate cancer tumor growth.Molecular cancer therapeutics · 2014Article
- Identification of human disease genes from interactome network using graphlet interaction.PloS one · 2014Article
- Neem (Azadirachta indica): prehistory to contemporary medicinal uses to humankind.Asian Pacific journal of tropical biomedicine · 2013Article
- Antiangiogenic Effects and Therapeutic Targets of Azadirachta indica Leaf Extract in Endothelial Cells.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- A review of the anticancer activity of Azadirachta indica (Neem) in oral cancer.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advanced prostate cancer has significant long-term morbidity, and there is a growing interest in alternative and complimentary forms of therapy that will improve the outcomes of patients. Azadirachta indica (common name: neem) contains multiple active compounds that have potent anti-inflammatory and anticancer properties. The present study investigates the novel targets of the anticancer activity of ethanol extract of neem leaves (EENL) in vitro and evaluates the in vivo efficacy in the prostate cancer models. Analysis of the components in the EENL by mass spectrometry suggests the presence of 2',3'-dehydrosalannol, 6-desacetyl nimbinene, and nimolinone. Treatment of C4-2B and PC-3M-luc2 prostate cancer cells with EENL inhibited the cell proliferation. Genome-wide expression profiling, using oligonucleotide microarrays, revealed genes differentially expressed with EENL treatment in prostate cancer cells. Functional analysis unveiled that most of the up-regulated genes were associated with cell death, and drug metabolism, and the down-regulated genes were associated with cell cycle, DNA replication, recombination, and repair functions. Quantitative PCR confirmed significant up-regulation of 40 genes and immunoblotting revealed increase in the protein expression levels of HMOX1, AKR1C2, AKR1C3, and AKR1B10. EENL treatment inhibited the growth of C4-2B and PC-3M-luc2 prostate cancer xenografts in nude mice. The suppression of tumor growth is associated with the formation of hyalinized fibrous tumor tissue and the induction of cell death by apoptosis. These results suggest that EENL-containing natural bioactive compounds could have potent anticancer property and the regulation of multiple cellular pathways could exert pleiotrophic effects in prevention and treatment of prostate cancer.
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