ArticleMarine biotechnology (New York, N.Y.)2011
Functional divergences of GAPDH isoforms during early development in two perciform fish species.
Article in Marine biotechnology (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 12 citations in OpenAlex.
- Multi-Omics Integration Reveals Synergistic Metabolic Rewiring Underpinning Growth Acceleration in a Hybrid Pompano "Chenhai No. 1".Animals : an open access journal from MDPI · 2026Article
- Deciphering European Sea Bass (International journal of molecular sciences · 2025Article
- Reference gene identification and validation for quantitative real-time PCR studies in developing Xenopus laevis.Scientific reports · 2018Article
- Identification, Phylogeny, and Function of fabp2 Paralogs in Two Non-Model Teleost Fish Species.Marine biotechnology (New York, N.Y.) · 2015Article
- The Atlantic Bonito (Sarda sarda, Bloch 1793) transcriptome and detection of differential expression during larvae development.PloS one · 2014Article
- Expression of developmental-stage-specific genes in the gilthead sea bream Sparus aurata L.Marine biotechnology (New York, N.Y.) · 2013Article
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4 authors at 1 institution in 1 country.
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Abstract
Glyceraldehyde-3-phospate dehydrogenase (GAPDH) is involved in basic cell catabolic processes and, as it is thought to be continuously expressed, belongs to the group of housekeeping genes. Thus, it is frequently used as an internal control in quantitative gene expression studies. However, the evidence of different expression patterns in a broad range of organisms and tissues, as well as the occurrence of different isoforms, shows that GAPDH has to be reevaluated as an internal control in qPCR studies, and its annotation has to be enriched. GAPDH has been shown to be involved in the pathway of energy and carbon molecule supply as well as in transcription and apoptosis. In the present study, we isolated the two isoforms, GAPDH-1 and GAPDH-2, of the gilthead sea bream (Sparus aurata) and the European sea bass (Dicentrarchus labrax). We inferred the phylogenetic relationships to ten other fish species and gave the gene structure of both genes. We further investigated gene expression analysis in both species for different developmental stages showing divergent gene expression of the two isoforms and the possible function of GAPDH-1 as a maternal gene.
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