ArticleAge (Dordrecht, Netherlands)2012
Aging blunts hyperventilation-induced hypocapnia and reduction in cerebral blood flow velocity during maximal exercise.
Article in Age (Dordrecht, Netherlands), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Comparison of cerebrovascular reactivity recovery following high-intensity interval training and moderate-intensity continuous training.Physiological reports · 2020Trial
- Effects of acute bouts of endurance exercise on retinal vessel diameters are age and intensity dependent.Age (Dordrecht, Netherlands) · 2014Trial
- Heartbeat-evoked potentials following voluntary hyperventilation in epilepsy patients: respiratory influences on cardiac interoception.Frontiers in neuroscience · 2024Article
- Effects of Physical Exercise on Cerebral Blood Velocity in Older Adults: A Systematic Review and Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2023Review
- Article
- EEG Characteristics to Hyperventilation by Age and Sex in Patients With Various Neurological Disorders.Frontiers in neurology · 2021Article
- Temporal evolution of neurovascular coupling recovery following moderate- and high-intensity exercise.Physiological reports · 2021Article
- The effect of age on cerebral blood flow responses during repeated and sustained stand to sit transitions.Physiological reports · 2020Article
- Dynamic cerebral autoregulation across the cardiac cycle during 8 hr of recovery from acute exercise.Physiological reports · 2020Article
- The Effect of Stroke on Middle Cerebral Artery Blood Flow Velocity Dynamics During Exercise.Journal of neurologic physical therapy : JNPT · 2019Article
- Effect of healthy aging and sex on middle cerebral artery blood velocity dynamics during moderate-intensity exercise.American journal of physiology. Heart and circulatory physiology · 2018Article
- Cerebrovascular Function in the Large Arteries Is Maintained Following Moderate Intensity Exercise.Frontiers in physiology · 2018Article
- The impact of age on cerebral perfusion, oxygenation and metabolism during exercise in humans.The Journal of physiology · 2016Review
- Role of CO2 in the cerebral hyperemic response to incremental normoxic and hyperoxic exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Cerebrovascular responses to submaximal exercise in women with COPD.BMC pulmonary medicine · 2014Article
- Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges.European journal of applied physiology · 2014Review
- Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: effect of age and 12-week exercise training.Age (Dordrecht, Netherlands) · 2013Article
- Cerebral perfusion, oxygenation and metabolism during exercise in young and elderly individuals.The Journal of physiology · 2013Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
Cerebral blood flow (CBF) increases from rest to ∼60% of peak oxygen uptake (VO(2peak)) and thereafter decreases towards baseline due to hyperventilation-induced hypocapnia and subsequent cerebral vasoconstriction. It is unknown what happens to CBF in older adults (OA), who experience a decline in CBF at rest coupled with a blunted ventilatory response during VO(2peak). In 14 OA (71 ± 10 year) and 21 young controls (YA; 23 ± 4 years), we hypothesized that OA would experience less hyperventilation-induced cerebral vasoconstriction and therefore an attenuated reduction in CBF at VO(2peak). Incremental exercise was performed on a cycle ergometer, whilst bilateral middle cerebral artery blood flow velocity (MCA V (mean); transcranial Doppler ultrasound), heart rate (HR; ECG) and end-tidal PCO(2) (P(ET)CO(2)) were monitored continuously. Blood pressure (BP) was monitored intermittently. From rest to 50% of VO(2peak), despite greater elevations in BP in OA, the change in MCA V(mean) was greater in YA compared to OA (28% vs. 15%, respectively; P < 0.0005). In the YA, at intensities >70% of VO(2peak), the hyperventilation-induced declines in both P(ET)CO(2) (14 mmHg (YA) vs. 4 mmHg (OA); P < 0.05) and MCA V(mean) (-21% (YA) vs. -7% (OA); P < 0.0005) were greater in YA compared to OA. Our findings show (1), from rest-to-mild intensity exercise (50% VO(2peak)), elevations in CBF are reduced in OA and (2) age-related declines in hyperventilation during maximal exercise result in less hypocapnic-induced cerebral vasoconstriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.