ArticleDigestive diseases and sciences2011
Expression of ADAMTS12 in colorectal cancer-associated stroma prevents cancer development and is a good prognostic indicator of colorectal cancer.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor.Journal of medicinal chemistry · 2024Article
- ADAMTS Proteases: Their Multifaceted Role in the Regulation of Cancer Metastasis.Diseases & research · 2024Article
- An Integrated Pan-Cancer Analysis of ADAMTS12 and Its Potential Implications in Pancreatic Adenocarcinoma.Frontiers in oncology · 2022Article
- ADAMTS-12: Functions and Challenges for a Complex Metalloprotease.Frontiers in molecular biosciences · 2021Review
- ADAMTS12 acts as a cancer promoter in colorectal cancer via activating the Wnt/β-catenin signaling pathwayAnnals of translational medicine · 2020Article
- Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients.Diagnostics (Basel, Switzerland) · 2020Article
- A metalloproteinase of the disintegrin and metalloproteinases and the ThromboSpondin Motifs 6 as a novel marker for colon cancer: functional experiments.Genetics and molecular biology · 2020Article
- Establishment of a 5-gene risk model related to regulatory T cells for predicting gastric cancer prognosis.Cancer cell international · 2020Article
- Prognostic Values for the mRNA Expression of the ADAMTS Family of Genes in Gastric Cancer.Journal of oncology · 2020Article
- Genes associated with bowel metastases in ovarian cancer.Gynecologic oncology · 2019Article
- Long non-coding RNA AK001058 regulates tumor growth and angiogenesis in colorectal cancer via methylation of ADAMTS12.American journal of translational research · 2019Article
- AK001058 promotes the proliferation and migration of colorectal cancer cells by regulating methylation of ADAMTS12.American journal of translational research · 2019Article
- MicroRNA-32 Regulates Development and Progression of Hepatocellular Carcinoma by Targeting ADAMTS9 and Affects Its Prognosis.Medical science monitor basic research · 2018Article
- Overexpression of PRDM13 inhibits glioma cells via Rho and GTP enzyme activation protein.International journal of molecular medicine · 2018Article
- Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis.EBioMedicine · 2018Article
- Differential gene expression profiling of matched primary renal cell carcinoma and metastases reveals upregulation of extracellular matrix genes.Annals of oncology : official journal of the European Society for Medical Oncology · 2017Article
- Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells.Oncotarget · 2017Article
- ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.Mediators of inflammation · 2014Review
- ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis.BMB reports · 2013Review
- ADAMTS-12 metalloprotease is necessary for normal inflammatory response.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this study was to investigate the role of ADAMTS12 in colorectal cancer progression and to examine whether ADAMTS-12 can be considered as a prognostic indicator for colorectal cancer.
methodsThis study was performed on formalin-fixed paraffin-embedded resected specimens obtained from 112 patients with colorectal cancer. The expression level of ADAMTS12 was investigated by immunohistochemical staining to assess the relationship between ADAMTS12 expression and the clinicopathologic factors and to study the prognostic significance of ADAMTS12 in colorectal cancer patients.
resultsADAMTS12 expression was mainly localized in the fibroblasts adjacent to the tumor cells or in macrophages in front of the invasive cancer margins. The ADAMTS12 expression was significantly correlated with the tumor histological grade, depth of tumor invasion, lymph node metastasis, and Dukes' stage. Patients with low or no ADAMTS12 expression in the tumor stroma had a significantly poor overall survival or disease-free survival.
conclusionThe expression of ADAMTS12 in colorectal cancer stroma plays an important role in inhibiting tumor development. Patients with ADAMTS12 expression showed better prognosis than those without ADAMTS12 expression. Thus, ADAMTS12 expression may be a good prognostic marker for colorectal cancer.
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