ArticleDigestive diseases and sciences2011
Serotonin transporter and G protein beta 3 subunit gene polymorphisms in Greeks with irritable bowel syndrome.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- No association of G-protein beta polypeptide 3 polymorphism with irritable bowel syndrome: evidence from a meta-analysis.World journal of gastroenterology · 2014Pooled it
- Pooled it
- G protein beta 3(Oncotarget · 2018Article
- Genetic epidemiology of irritable bowel syndrome.World journal of gastroenterology · 2015Review
- Gene polymorphisms associated with functional dyspepsia.World journal of gastroenterology · 2015Review
- Association Between SLC6A4 Serotonin Transporter Gene Lainked Polymorphic Region and ADRA2A -1291C>G and Irritable Bowel Syndrome in Korea.Journal of neurogastroenterology and motility · 2014Article
- A genetic association study of single nucleotide polymorphisms in GNβ3 and COMT in elderly patients with irritable bowel syndrome.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Association study of serotonin transporter SLC6A4 gene with Chinese Han irritable bowel syndrome.PloS one · 2014Article
- Is There Enough Evidence for the Association of GNβ3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome?Journal of neurogastroenterology and motility · 2012Article
- Polymorphisms of the Serotonin Transporter Gene and G-Protein β3 Subunit Gene in Korean Children with Irritable Bowel Syndrome and Functional Dyspepsia.Gut and liver · 2012Article
- Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study.Journal of neurogastroenterology and motility · 2011Article
- Serotonin transporter gene polymorphism may be associated with functional dyspepsia in a Japanese population.BMC medical genetics · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolymorphisms in the serotonin transporter (SERT) and G protein β3 subunit (GNB3) genes might contribute to the pathophysiology of irritable bowel syndrome (IBS). Association studies of SERT and GNB3 polymorphisms and IBS have shown diverse results among different populations, which might be due to subject composition differences.
aimsThe aim of the study was to assess the potential association between SERT and GNB3 polymorphisms and IBS in Greeks.
methodsA total of 124 patients with IBS diagnosed according to the Rome III criteria and 238 healthy individuals were included in the study. SERT and GNB3 gene polymorphisms were genotyped using polymerase chain reaction-based methods.
resultsIt was shown that the frequencies of the SS genotype and S allele of the serotonin transporter polymorphism were significantly associated with IBS (P = 0.0314 and P = 0.019, respectively). TT genotype and T allele frequencies of G protein β3 subunit showed also significant difference between the IBS patients and healthy controls IBS (P = 0.0163 and P = 0.0001, respectively). None of the clinical symptoms analyzed was significantly associated with the polymorphisms tested.
conclusionsThe results suggest that SERT and GNB3 gene polymorphisms might be associated with irritable bowel syndrome predisposition in Greeks.
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