Evidence map›Paper›PMID 21559534›Full record

ReviewChemical communications (Cambridge, England)2011

De novo synthesis of natural products via the asymmetric hydration of polyenes.

Yanping Wang, Yalan Xing, Qi Zhang, George A O'Doherty

Abstract readReview
In one paragraph

Review in Chemical communications (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Total and Formal Syntheses of Fostriecin.Organic chemistry frontiers : an international journal of organic chemistry · 2020
    Article
  3. Article
  4. Convergent synthesis of deoxypropionates.Angewandte Chemie (International ed. in English) · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yanping WangDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.
Yalan Xing
Qi Zhang
George A O'Doherty

Funding

De Novo Synthesis of OligosaccharidesR01GM090259 · NIGMS · WEST VIRGINIA UNIVERSITY · PI O'DOHERTY, GEORGE A · 2009 to 2012
$1.2M
De Novo Synthesis for MedChem on SugarsR01GM088839 · NIGMS · WEST VIRGINIA UNIVERSITY · PI O'DOHERTY, GEORGE A · 2009 to 2010
$604k
NIGMS NIH HHS R01 GM088839NIGMS NIH HHS R01 GM090259
6 · The paper itself

Abstract

For the last ten years our group has been working toward the development of an asymmetric hydration approach to polyketide natural products based on the regioselective hydration of di- and tri-enoates. Key to the success of this approach is the recognition that both high regiocontrol and asymmetric induction could be obtained by the use of a Sharpless asymmetric dihydroxylation reaction. Herein we describe the development of the method and its application to natural product total synthesis.

Indexed as

Biological ProductsBridged Bicyclo Compounds, HeterocyclicCatalysisOxidation-ReductionPolyenesStereoisomerismapicularen ABiological ProductsBridged Bicyclo Compounds, HeterocyclicPolyenes

Identifiers

PMID21559534
PMCPMC5815319

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.