ArticlePloS one2011
Nocturnal hypoxia and loss of kidney function.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03319888 (Effect of CPAP in the Worsening of Renal Function in Early Stages of Chronic Kidney Disease), which is not on this map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of CPAP in the Worsening of Renal Function in Early Stages of Chronic Kidney Disease (CKD)
Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Kidney transplantation: a possible solution to obstructive sleep apnea in patients with end-stage kidney disease.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Obstructive sleep apnea syndrome and risk of renal impairment: a systematic review and meta-analysis with trial sequential analysis.Sleep & breathing = Schlaf & Atmung · 2021Pooled it
- The association of obstructive sleep apnea and renal outcomes-a systematic review and meta-analysis.BMC nephrology · 2017Pooled it
- Trial
- Interaction between oxygen saturation and renal function on 30-day mortality in emergency department patients.Scientific reports · 2026Article
- Development and validation of an explainable predictive model for the risk of moderate-to-severe obstructive sleep apnea in resistant hypertensive patients.Scientific reports · 2025Article
- Nocturnal hypoxemic burden is associated with worsening prognosis of chronic kidney disease in patients with type 2 diabetes.Cardiovascular diabetology · 2025Observational
- The impact of high altitude (hypobaric hypoxia) on insulin resistance in humans.Journal of physiology and biochemistry · 2025Review
- Bidirectional Interactions Between Obstructive Sleep Apnea and Chronic Kidney Disease- A Review.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Sleep disorders in chronic kidney disease.Nature reviews. Nephrology · 2024Review
- Hypoxia-Induced Insulin Resistance Mediates the Elevated Cardiovascular Risk in Patients with Obstructive Sleep Apnea: A Comprehensive Review.Reviews in cardiovascular medicine · 2024Review
- Obstructive sleep apnea: transition from pathophysiology to an integrative disease model.Journal of sleep research · 2022Review
- Article
- Bidirectional relationships of comorbidity with obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Article
- Article
- Obstructive sleep apnea-induced multi-organ dysfunction after elective coronary artery bypass surgery in coronary heart disease patients.Journal of thoracic disease · 2020Article
- Obstructive Sleep Apnea, Other Sleep Characteristics, and Risk of CKD in the Atherosclerosis Risk in Communities Sleep Heart Health Study.Journal of the American Society of Nephrology : JASN · 2020Article
- Interrelationship among Obstructive Sleep Apnea, Renal Function and Survival: A Cohort Study.International journal of environmental research and public health · 2020Observational
- Obstructive sleep apnea and the risk of gout: a population-based case-control study.Arthritis research & therapy · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAlthough obstructive sleep apnea (OSA) is more common in patients with kidney disease, whether nocturnal hypoxia affects kidney function is unknown.
methodsWe studied all adult subjects referred for diagnostic testing of sleep apnea between July 2005 and December 31 2007 who had serial measurement of their kidney function. Nocturnal hypoxia was defined as oxygen saturation (SaO2) below 90% for ≥12% of the nocturnal monitoring time. The primary outcome, accelerated loss of kidney function, was defined as a decline in estimated glomerular filtration rate (eGFR) ≥4 ml/min/1.73 m(2) per year.
results858 participants were included and followed for a mean study period of 2.1 years. Overall 374 (44%) had nocturnal hypoxia, and 49 (5.7%) had accelerated loss of kidney function. Compared to controls without hypoxia, patients with nocturnal hypoxia had a significant increase in the adjusted risk of accelerated kidney function loss (odds ratio (OR) 2.89, 95% confidence interval [CI] 1.25, 6.67).
conclusionNocturnal hypoxia was independently associated with an increased risk of accelerated kidney function loss. Further studies are required to determine whether treatment and correction of nocturnal hypoxia reduces loss of kidney function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.