ArticlePloS one2011
PDFR and CRY signaling converge in a subset of clock neurons to modulate the amplitude and phase of circadian behavior in Drosophila.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Circadian control of a sex-specific behavior ineLife · 2026Article
- A functional clock in only two dorsal clock neurons is sufficient to restore the basal circadian activity pattern ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Circadian rhythms are more resilient to pacemaker neuron disruption in female Drosophila.PLoS biology · 2025Article
- Mutual coupling of neurons in the circadian master clock: What we can learn from fruit flies.Neurobiology of sleep and circadian rhythms · 2025Article
- Light and dopamine impact two circadian neurons to promote morning wakefulness.Current biology : CB · 2024Article
- Tango-seq: overlaying transcriptomics on connectomics to identify neurons downstream ofbioRxiv : the preprint server for biology · 2024Article
- A subclass of evening cells promotes the switch from arousal to sleep at dusk.Current biology : CB · 2024Article
- Light and dopamine impact two circadian neurons to promote morning wakefulness.bioRxiv : the preprint server for biology · 2024Article
- Article
- Organismal landscape of clock cells and circadian gene expression inbioRxiv : the preprint server for biology · 2023Article
- Connectomic analysis of theeLife · 2022Article
- Regulation of PDF receptor signaling controlling daily locomotor rhythms in Drosophila.PLoS genetics · 2022Article
- Under warm ambient conditions, Drosophila melanogaster suppresses nighttime activity via the neuropeptide pigment dispersing factor.Genes, brain, and behavior · 2022Article
- The Neuronal Circuit of the Dorsal Circadian Clock Neurons inFrontiers in physiology · 2022Article
- Nucleotide Variation inFrontiers in physiology · 2022Article
- The E3 ubiquitin ligase adaptorProceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Neuropeptide PDF Is Crucial for Delaying the Phase ofJournal of biological rhythms · 2021Article
- Daily rewiring of a neural circuit generates a predictive model of environmental light.Science advances · 2021Article
- Flies as models for circadian clock adaptation to environmental challenges.The European journal of neuroscience · 2020Review
- Entrainment of theNeuroscience insights · 2020Review
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Authors and funding
3 authors.
Funding
Abstract
backgroundTo synchronize their molecular rhythms, circadian pacemaker neurons must input both external and internal timing cues and, therefore, signal integration between sensory information and internal clock status is fundamental to normal circadian physiology. METHODOLOGY/PRINCIPAL
findingsWe demonstrate the specific convergence of clock-derived neuropeptide signaling with that of a deep brain photoreceptor. We report that the neuropeptide PDF receptor and the circadian photoreceptor CRYPTOCROME (CRY) are precisely co-expressed in a subset of pacemakers, and that these pathways together provide a requisite drive for circadian control of daily locomotor rhythms. These convergent signaling pathways influence the phase of rhythm generation, but also its amplitude. In the absence of both pathways, PER rhythms were greatly reduced in only those specific pacemakers that receive convergent inputs and PER levels remained high in the nucleus throughout the day. This suggested a large-scale dis-regulation of the pacemaking machinery. Behavioral rhythms were likewise disrupted: in light:dark conditions they were aberrant, and under constant dark conditions, they were lost. CONCLUSIONS/SIGNIFICANCE: We speculate that the convergence of environmental and clock-derived signals may produce a coincident detection of light, synergistic responses to it, and thus more accurate and more efficient re-setting properties.
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