ArticlePloS one2011
Microspectroscopic evidence of cretaceous bone proteins.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Preserving Fossilized Soft Tissues: Advancing Proteomics and Unveiling the Evolutionary History of Cancer in Dinosaurs.Biology · 2025Article
- Taphonomic variation in vascular remains from Mesozoic non-avian dinosaurs.Scientific reports · 2025Article
- Contributions of Resin Cast Etching to Visualising the Osteocyte Lacuno-Canalicular Network Architecture in Bone Biology and Tissue Engineering.Calcified tissue international · 2023Review
- Biomolecular histology as a novel proxy for ancient DNA and protein sequence preservation.Ecology and evolution · 2022Article
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- Molecular tests support the viability of rare earth elements as proxies for fossil biomolecule preservation.Scientific reports · 2020Article
- Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage.National science review · 2020Article
- Identifying medullary bone in extinct avemetatarsalians: challenges, implications and perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
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- Mechanisms of soft tissue and protein preservation in Tyrannosaurus rex.Scientific reports · 2019Article
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- Preservation potential of keratin in deep time.PloS one · 2018Article
- Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP.Nature communications · 2017Article
- Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein.Journal of proteome research · 2017Article
- Testing the Hypothesis of Biofilm as a Source for Soft Tissue and Cell-Like Structures Preserved in Dinosaur Bone.PloS one · 2016Article
- Spectroscopic Studies on Organic Matter from Triassic Reptile Bones, Upper Silesia, Poland.PloS one · 2016Article
- Proteome degradation in fossils: investigating the longevity of protein survival in ancient bone.Rapid communications in mass spectrometry : RCM · 2014Article
- A role for iron and oxygen chemistry in preserving soft tissues, cells and molecules from deep time.Proceedings. Biological sciences · 2014Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low concentrations of the structural protein collagen have recently been reported in dinosaur fossils based primarily on mass spectrometric analyses of whole bone extracts. However, direct spectroscopic characterization of isolated fibrous bone tissues, a crucial test of hypotheses of biomolecular preservation over deep time, has not been performed. Here, we demonstrate that endogenous proteinaceous molecules are retained in a humerus from a Late Cretaceous mosasaur (an extinct giant marine lizard). In situ immunofluorescence of demineralized bone extracts shows reactivity to antibodies raised against type I collagen, and amino acid analyses of soluble proteins extracted from the bone exhibit a composition indicative of structural proteins or their breakdown products. These data are corroborated by synchrotron radiation-based infrared microspectroscopic studies demonstrating that amino acid containing matter is located in bone matrix fibrils that express imprints of the characteristic 67 nm D-periodicity typical of collagen. Moreover, the fibrils differ significantly in spectral signature from those of potential modern bacterial contaminants, such as biofilms and collagen-like proteins. Thus, the preservation of primary soft tissues and biomolecules is not limited to large-sized bones buried in fluvial sandstone environments, but also occurs in relatively small-sized skeletal elements deposited in marine sediments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.