ArticleEURASIP journal on bioinformatics & systems biology2011
Modeling signal transduction leading to synaptic plasticity: evaluation and comparison of five models.
Article in EURASIP journal on bioinformatics & systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comparison of rule- and ordinary differential equation-based dynamic model of DARPP-32 signalling network.PeerJ · 2022Article
- Replicability or reproducibility? On the replication crisis in computational neuroscience and sharing only relevant detail.Journal of computational neuroscience · 2018Article
- Challenges in Reproducibility, Replicability, and Comparability of Computational Models and Tools for Neuronal and Glial Networks, Cells, and Subcellular Structures.Frontiers in neuroinformatics · 2018Article
- Reproducibility and Comparability of Computational Models for Astrocyte Calcium Excitability.Frontiers in neuroinformatics · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
An essential phenomenon of the functional brain is synaptic plasticity which is associated with changes in the strength of synapses between neurons. These changes are affected by both extracellular and intracellular mechanisms. For example, intracellular phosphorylation-dephosphorylation cycles have been shown to possess a special role in synaptic plasticity. We, here, provide the first computational comparison of models for synaptic plasticity by evaluating five models describing postsynaptic signal transduction networks. Our simulation results show that some of the models change their behavior completely due to varying total concentrations of protein kinase and phosphatase. Furthermore, the responses of the models vary when models are compared to each other. Based on our study, we conclude that there is a need for a general setup to objectively compare the models and an urgent demand for the minimum criteria that a computational model for synaptic plasticity needs to meet.
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Registered trials
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