ArticlePloS one2011
Maternal arterial stiffness in women who subsequently develop pre-eclampsia.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Predictive accuracy of the first trimester Doppler scan: a meta-study.Wiener medizinische Wochenschrift (1946) · 2015Pooled it
- Pre-Eclampsia and Maternal Cardiovascular Function: Insights Into Pathophysiology and Care (Scientific Impact Paper No. 79).BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Postpartum Cardiovascular Health in African Women Following Pre-Eclampsia: A Prospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Comparison of Central Aortic Pressure between Women with Preeclampsia and Normotensive Postpartum Women from an Urban Region of Western Mexico.Medicina (Kaunas, Lithuania) · 2023Article
- A mathematical model of vascular and hemodynamics changes in early and late forms of preeclampsia.Physiological reports · 2023Article
- Altered cardiac and vascular stiffness in pregnancy after a hypertensive pregnancy.Journal of human hypertension · 2023Article
- Review
- Treatment with apocynin selectively restores hippocampal arteriole function and seizure-induced hyperemia in a model of preeclampsia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Highlighting the Mechanistic Relationship Between Perinatal Depression and Preeclampsia: A Scoping Review.Women's health reports (New Rochelle, N.Y.) · 2022Article
- Center-To-Periphery Arterial Stiffness Gradient Is Attenuated and/or Reversed in Pregnancy-Associated Hypertension.Frontiers in cardiovascular medicine · 2021Article
- Maternal Vascular Health in Pregnancy and Postpartum After Assisted Reproduction.Hypertension (Dallas, Tex. : 1979) · 2020Article
- A Systematic Review of Vascular Structure and Function in Pre-eclampsia: Non-invasive Assessment and Mechanistic Links.Frontiers in cardiovascular medicine · 2019Review
- The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- Changes of Arterial Pulse Waveform Characteristics with Gestational Age during Normal Pregnancy.Scientific reports · 2018Article
- Is there a differential impact of parity on factors regulating maternal peripheral resistance?Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Abnormal uterine artery remodelling in the stroke prone spontaneously hypertensive rat.Placenta · 2016Article
- Pregnancy induces persistent changes in vascular compliance in primiparous women.American journal of obstetrics and gynecology · 2015Article
- Pregnancy characteristics and women's future cardiovascular health: an underused opportunity to improve women's health?Epidemiologic reviews · 2014Review
- Prepregnancy Vascular Dysfunction in Women who Subsequently Develop Hypertension During Pregnancy.Pregnancy hypertension · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesPre-eclampsia (PE) is associated with profound changes in the maternal cardiovascular system. The aim of the present study was to assess whether alterations in the maternal arterial stiffness precede the onset of PE in at risk women. METHODOLOGY/PRINCIPAL
findingsThis was a cross sectional study involving 70 pregnant women with normal and 70 women with abnormal uterine artery Doppler examination at 22-24 weeks of gestation. All women had their arterial stiffness (augmentation index and pulse wave velocity of the carotid-femoral and carotid-radial parts of the arterial tree) assessed by applanation tonometry in the second trimester of pregnancy, at the time of the uterine artery Doppler imaging. Among the 140 women participating in the study 29 developed PE (PE group) and 111 did not (non-PE group). Compared to the non-PE group, women that developed PE had higher central systolic (94.9 ± 8.6 mmHg vs 104.3 ± 11.1 mmHg; p = < 0.01) and diastolic (64.0 ± 6.0 vs 72.4 ± 9.1; p < 0.01) blood pressures. All the arterial stiffness indices were adjusted for possible confounders and expressed as multiples of the median (MoM) of the non-PE group. The adjusted median augmentation index was similar between the two groups (p = 0.84). The adjusted median pulse wave velocities were higher in the PE group compared to the non-PE group (carotid-femoral: 1.10 ± 0.14 MoMs vs 0.99 ± 0.11 MoMs; p < 0.01 and carotid-radial: 1.08 ± 0.12 MoMs vs 1.0 ± 0.11 MoMs; p < 0.01). CONCLUSIONS/SIGNIFICANCE: Increased maternal arterial stiffness, as assessed by pulse wave velocity, predates the development of PE in at risk women.
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