ArticleInternational journal of Alzheimer's disease2011
Function and comorbidities of apolipoprotein e in Alzheimer's disease.
Article in International journal of Alzheimer's disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Investigation of base excision repair gene variants in late-onset Alzheimer's disease.PloS one · 2019Trial
- Gene therapy for age-related macular degeneration: a promising frontier in vision preservation.Cell communication and signaling : CCS · 2025Review
- Alzheimer's Disease-Related Epigenetic Changes: Novel Therapeutic Targets.Molecular neurobiology · 2024Review
- Article
- Behavioral and cognitive performance of humanized APOEε3/ε3 liver mice in relation to plasma apolipoprotein E levels.Scientific reports · 2023Article
- Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration.JCI insight · 2021Article
- Complement activation, lipid metabolism, and mitochondrial injury: Converging pathways in age-related macular degeneration.Redox biology · 2020Review
- Homozygosity in theFrontiers in endocrinology · 2020Article
- Apolipoprotein E4: A Risk Factor for Successful Cognitive Aging.Dementia and neurocognitive disorders · 2016Review
- Estrogens, Neuroinflammation, and Neurodegeneration.Endocrine reviews · 2016Review
- Effects of rs3846662 Variants on HMGCR mRNA and Protein Levels and on Markers of Alzheimer's Disease Pathology.Journal of molecular neuroscience : MN · 2016Article
- Body fluid biomarkers in Alzheimer's disease.Annals of translational medicine · 2015Review
- Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease.Frontiers in aging neuroscience · 2015Review
- Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E2/4 Carriers: The Effect of an Apparent Duality.Journal of lipids · 2015Article
- APOE2 enhances neuroprotection against Alzheimer's disease through multiple molecular mechanisms.Molecular psychiatry · 2014Article
- Beta-amyloid auto-antibodies are reduced in Alzheimer's disease.Journal of neuroimmunology · 2014Article
- Alzheimer's disease: review of hormone therapy trials and implications for treatment and prevention after menopause.The Journal of steroid biochemistry and molecular biology · 2014Review
- Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal protease.PloS one · 2014Article
- The potential applications of Apolipoprotein E in personalized medicine.Frontiers in aging neuroscience · 2014Review
- Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease.Frontiers in aging neuroscience · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD)-the most common type of dementia among the elderly-represents one of the most challenging and urgent medical mysteries affecting our aging population. Although dominant inherited mutation in genes involved in the amyloid metabolism can elicit familial AD, the overwhelming majority of AD cases, dubbed sporadic AD, do not display this Mendelian inheritance pattern. Apolipoprotein E (APOE), the main lipid carrier protein in the central nervous system, is the only gene that has been robustly and consistently associated with AD risk. The purpose of the current paper is thus to highlight the pleiotropic roles and the structure-function relationship of APOE to stimulate both the functional characterization and the identification of novel lipid homeostasis-related molecular targets involved in AD.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.