ArticlePloS one2011
The role of pH fronts in reversible electroporation.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 80 citations in OpenAlex.
- Article
- Efficient electroporation in primary cells with PEDOT:PSS electrodes.Science advances · 2024Article
- Microphysiological system with integrated sensors to study the effect of pulsed electric field.Scientific reports · 2024Article
- Effects of bipolar irreversible electroporation with different pulse durations in a prostate cancer mouse model.Scientific reports · 2024Article
- Harnessing the Electrochemical Effects of Electroporation-Based Therapies to Enhance Anti-tumor Immune Responses.Annals of biomedical engineering · 2024Article
- Effect of Experimental Electrical and Biological Parameters on Gene Transfer by Electroporation: A Systematic Review and Meta-Analysis.Pharmaceutics · 2022Review
- High-Intensity Pulsed Electromagnetic Field-Mediated Gene Electrotransfection In Vitro.International journal of molecular sciences · 2022Article
- Numerical mesoscale tissue model of electrochemotherapy in liver based on histological findings.Scientific reports · 2022Article
- Article
- The impact of impaired DNA mobility on gene electrotransfer efficiency: analysis in 3D model.Biomedical engineering online · 2021Article
- Electroporation as the Immunotherapy Strategy for Cancer in Veterinary Medicine: State of the Art in Latin America.Vaccines · 2020Review
- Article
- Toward a clinical real time tissue ablation technology: combining electroporation and electrolysis (E2).PeerJ · 2020Article
- A Study on Nonthermal Irreversible Electroporation of the Thyroid.Technology in cancer research & treatment · 2019Article
- Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts.Chemical reviews · 2018Review
- "Super-active surveillance": MRI ultrasound fusion biopsy and ablation for less invasive management of prostate cancer.Gland surgery · 2018Review
- Simultaneous electroporation and dielectrophoresis in non-electrolytic micro/nano-electroporation.Scientific reports · 2018Article
- Article
- Induction of rapid, reproducible hepatic ablations using next-generation, high frequency irreversible electroporation (H-FIRE) in vivo.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2016Article
- Electroporation on microchips: the harmful effects of pH changes and scaling down.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present experimental measurements and theoretical predictions of ion transport in agar gels during reversible electroporation (ECT) for conditions typical to many clinical studies found in the literature, revealing the presence of pH fronts emerging from both electrodes. These results suggest that pH fronts are immediate and substantial. Since they might give rise to tissue necrosis, an unwanted condition in clinical applications of ECT as well as in irreversible electroporation (IRE) and in electrogenetherapy (EGT), it is important to quantify their extent and evolution. Here, a tracking technique is used to follow the space-time evolution of these pH fronts. It is found that they scale in time as t(½), characteristic of a predominantly diffusive process. Comparing ECT pH fronts with those arising in electrotherapy (EChT), another treatment applying constant electric fields whose main goal is tissue necrosis, a striking result is observed: anodic acidification is larger in ECT than in EChT, suggesting that tissue necrosis could also be greater. Ways to minimize these adverse effects in ECT are suggested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.