ArticleFrontiers in neural circuits2011
Lateral Connectivity in the Olfactory Bulb is Sparse and Segregated.
Article in Frontiers in neural circuits, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- How the olfactory bulb maintains stable odor manifolds amid adaptation and representational drift.bioRxiv : the preprint server for biology · 2026Article
- Anatomical and Functional Connectivity at the Dendrodendritic Reciprocal Mitral Cell-Granule Cell Synapse: Impact on Recurrent and Lateral Inhibition.Frontiers in neural circuits · 2022Article
- Olfactory bulb granule cells: specialized to link coactive glomerular columns for percept generation and discrimination of odors.Cell and tissue research · 2021Article
- A Systematic Framework for Olfactory Bulb Signal Transformations.Frontiers in computational neuroscience · 2020Article
- A17 Amacrine Cells and Olfactory Granule Cells: Parallel Processors of Early Sensory Information.Frontiers in cellular neuroscience · 2020Review
- Strong, weak and neuron type dependent lateral inhibition in the olfactory bulb.Scientific reports · 2019Article
- Sparsened neuronal activity in an optogenetically activated olfactory glomerulus.Scientific reports · 2018Article
- Parallel odor processing by mitral and middle tufted cells in the olfactory bulb.Scientific reports · 2018Article
- Architecture of a mammalian glomerular domain revealed by novel volume electroporation using nanoengineered microelectrodes.Nature communications · 2018Article
- Intraglomerular gap junctions enhance interglomerular synchrony in a sparsely connected olfactory bulb network.The Journal of physiology · 2017Article
- Functional Role of Intracellular Calcium Receptor Inositol 1,4,5-Trisphosphate Type 1 in Rat Hippocampus after Neonatal Anoxia.PloS one · 2017Article
- Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb.Nature communications · 2016Article
- A Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Glomerular and Mitral-Granule Cell Microcircuits Coordinate Temporal and Spatial Information Processing in the Olfactory Bulb.Frontiers in computational neuroscience · 2016Article
- Synaptic clusters function as odor operators in the olfactory bulb.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Bulbar microcircuit model predicts connectivity and roles of interneurons in odor coding.PloS one · 2015Article
- SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction.Nature neuroscience · 2013Article
- Early olfactory processing in Drosophila: mechanisms and principles.Annual review of neuroscience · 2013Review
- Article
- A two-layer biophysical model of cholinergic neuromodulation in olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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6 authors.
Funding
Abstract
Lateral connections in the olfactory bulb were previously thought to be organized for center-surround inhibition. However, recent anatomical and physiological studies showed sparse and distributed interactions of inhibitory granule cells (GCs) which tended to be organized in columnar clusters. Little is known about how these distributed clusters are interconnected. In this study, we use transsynaptic tracing viruses bearing green or red fluorescent proteins to further elucidate mitral- and tufted-to-GC connectivity. Separate sites in the glomerular layer were injected with each virus. Columns with labeling from both viruses after transsynaptic spread show sparse red or green GCs which tended to be segregated. However, there was a higher incidence of co-labeled cells than chance would predict. Similar segregation of labeling is observed from dual injections into olfactory cortex. Collectively, these results suggest that neighboring mitral and tufted cells receive inhibitory inputs from segregated subsets of GCs, enabling inhibition of a center by specific and discontinuous lateral elements.
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