ArticleEuropean journal of clinical nutrition2011
Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring.
Article in European journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Vitamin A, C and/or E Intake During Pregnancy and Offspring Respiratory Health: A Systematic Review and Meta-Analysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Pooled it
- Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020Pooled it
- Effects of Fruit and Vegetable Consumption on Risk of Asthma, Wheezing and Immune Responses: A Systematic Review and Meta-Analysis.Nutrients · 2017Pooled it
- A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years.BMJ open · 2014Pooled it
- Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis.The American journal of clinical nutrition · 2013Pooled it
- Associations between maternal antioxidant intakes in pregnancy and infant allergic outcomes.Nutrients · 2012Trial
- Association between dietary carotenoid intakes and the risk of asthma in children and adolescents: evidence from the National Health and Nutrition Examination Survey 2007-2016.Translational pediatrics · 2024Article
- Dietary patterns and micronutrients in respiratory infections including COVID-19: a narrative review.BMC public health · 2024Review
- Scientific opinion on the tolerable upper intake level for folate.EFSA journal. European Food Safety Authority · 2023Article
- Maternal Macro- and Micronutrient Intake During Pregnancy: Does It Affect Allergic Predisposition in Offspring?Immunology and allergy clinics of North America · 2023Review
- Mineral Micronutrients in Asthma.Nutrients · 2021Review
- Association between toenail zinc concentrations and incidence of asthma among American young adults: The CARDIA study.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2021Article
- Allergy Modulation by N-3 Long Chain Polyunsaturated Fatty Acids and Fat Soluble Nutrients of the Mediterranean Diet.Frontiers in pharmacology · 2020Review
- Prenatal Diet and the Development of Childhood Allergic Diseases: Food for Thought.Current allergy and asthma reports · 2018Review
- Nutrition and Lung Growth.Nutrients · 2018Review
- Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood-Lack of Association with Tobacco Smoke Exposure.International journal of environmental research and public health · 2018Article
- Vitamin A and D intake in pregnancy, infant supplementation, and asthma development: the Norwegian Mother and Child Cohort.The American journal of clinical nutrition · 2018Article
- Diet and Asthma: Is It Time to Adapt Our Message?Nutrients · 2017Review
- Maternal Folate Intake during Pregnancy and Childhood Asthma in a Population-based Cohort.American journal of respiratory and critical care medicine · 2017Article
- Pediatric rhinitis risk factors.Experimental and therapeutic medicine · 2016Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe potential immune functions related to the damages induced by oxygen-free radicals suggest that antioxidants may have a role in the development of allergies. The objective was to investigate the association between maternal intake of antioxidants during pregnancy and the risk of asthma, rhinitis and eczema in 5-year-old children. SUBJECTS/
methodsThis study was on the basis of the Finnish Type 1 Diabetes Prediction and Prevention Nutrition Study, a population-based birth cohort study with 5-year follow-up. Complete information on maternal food frequency questionnaire data and ISAAC (International Study of Asthma and Allergies in Childhood)-based allergic outcomes were available for 2441 children. Cox proportional regression and logistic regression were used for the analyses.
resultsMaternal intake of any of the antioxidants was not significantly associated with the risk of asthma, rhinitis or eczema in the offspring, except for dietary intake of magnesium, which was independently associated with protection against eczema (OR 0.78; 95% CI 0.62-0.97).
conclusionMaternal intake of dietary magnesium during pregnancy may protect against the risk of eczema in the offspring. We did not confirm previous observations concerning other antioxidants. This may be due to the variable amount of antioxidant intake across studies and also indicative of the hypothesis that there may be a critical time window in pregnancy during which antioxidants might modify the risk of allergies in the offspring.
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Registered trials
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