ArticleBritish journal of cancer2011
Modifiable and fixed factors predicting quality of life in people with colorectal cancer.
Article in British journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Coriolus (Trametes) versicolor mushroom to reduce adverse effects from chemotherapy or radiotherapy in people with colorectal cancer.The Cochrane database of systematic reviews · 2022Pooled it
- Quality of life after rectal resection for cancer, with or without permanent colostomy.The Cochrane database of systematic reviews · 2012Pooled it
- Trial
- Developing a multivariable prediction model of global health-related quality of life in patients treated for rectal cancer: a prospective study in five countries.International journal of colorectal disease · 2024Trial
- A Randomized Controlled Trial of Mindfulness in Recovery from Colorectal Cancer.Chinese journal of integrative medicine · 2023Trial
- Trial
- Patient-reported symptom burden as a prognostic factor in treatment with first-line cetuximab plus chemotherapy for unresectable metastatic colorectal cancer: Results of Phase II QUACK trial.Cancer medicine · 2020Trial
- Trial
- Trial
- Trial
- Residential Fast-Food Exposures, Colorectal Cancer-Specific, and All-Cause Mortality: A Retrospective Study of CRC Cases from the Kentucky Cancer Registry.Nutrition and cancer · 2026Article
- Multimodal Machine Learning for Predicting Post-Surgery Quality of Life in Colorectal Cancer Patients.Journal of imaging · 2024Article
- Association between adherence to the American Cancer Society Nutrition and Physical Activity Guidelines and stool frequency among colon cancer survivors: a cohort study.Journal of cancer survivorship : research and practice · 2023Article
- Validation of the Thai Version of the Memorial Symptom Assessment Scaled - Short Form Among Cholangiocarcinoma Patients.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Symptoms and seeking supportive care and associations with quality of life after treatment for colon cancer: Results from the I CARE cohort study.European journal of cancer care · 2022Article
- Virtual reality for improving pain and pain-related symptoms in patients with advanced stage colorectal cancer: A pilot trial to test feasibility and acceptability.Palliative & supportive care · 2022Article
- Quality of Life and Psychological Wellbeing of Colorectal Cancer Survivors in the KSA.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- The influence of predictive nursing on the emotions and self-management abilities of post-colostomy rectal cancer patients.American journal of translational research · 2021Article
- Negative illness perceptions are related to poorer health-related quality of life among thyroid cancer survivors: Results from the PROFILES registry.Head & neck · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundPeople with colorectal cancer have impaired quality of life (QoL). We investigated what factors were most highly associated with it.
methodsFour hundred and ninety-six people with colorectal cancer completed questionnaires about QoL, functioning, symptoms, co-morbidity, cognitions and personal and social factors. Disease, treatment and co-morbidity data were abstracted from case notes. Multiple linear regression identified modifiable and unmodifiable factors independently predictive of global quality of life (EORTC-QLQ-C30).
resultsOf unmodifiable factors, female sex (P<0.001), more self-reported co-morbidities (P=0.006) and metastases at diagnosis (P=0.036) significantly predicted poorer QoL, but explained little of the variability in the model (R(2)=0.064). Adding modifiable factors, poorer role (P<0.001) and social functioning (P=0.003), fatigue (P=0.001), dyspnoea (P=0.001), anorexia (P<0.001), depression (P<0.001) and worse perceived consequences (P=0.013) improved the model fit considerably (R(2)=0.574). Omitting functioning subscales resulted in recent diagnosis (P=0.002), lower perceived personal control (P=0.020) and travel difficulties (P<0.001) becoming significant predictors.
conclusionMost factors affecting QoL are modifiable, especially symptoms (fatigue, anorexia, dyspnoea) and depression. Beliefs about illness are also important. Unmodifiable factors, including metastatic (or unstaged) disease at diagnosis, have less impact. There appears to be potential for interventions to improve QoL in patients with colorectal cancer.
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