ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2011
Physiopathological function of hematoside (GM3 ganglioside).
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Ganglioside GM3-Functionalized Reconstituted High-Density Lipoprotein (GM3-rHDL) as a Novel Nanocarrier Enhances Antiatherosclerotic Efficacy of Statins in apoEPharmaceutics · 2022Article
- Ceramide metabolism associated with chronic dietary nutrient surplus and diminished insulin sensitivity in the liver, muscle, and adipose tissue of cattle.Frontiers in physiology · 2022Article
- Insulin Receptor Isoforms in Physiology and Disease: An Updated View.Endocrine reviews · 2017Review
- Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.The Journal of biological chemistry · 2017Article
- Ganglioside-Lipid and Ganglioside-Protein Interactions Revealed by Coarse-Grained and Atomistic Molecular Dynamics Simulations.The journal of physical chemistry. B · 2017Article
- Histochemical and immunoelectron microscopic analysis of ganglioside GM3 in human kidney.Clinical and experimental nephrology · 2015Article
- Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes.American journal of respiratory and critical care medicine · 2015Article
- Identification of Ganglioside GM3 Molecular Species in Human Serum Associated with Risk Factors of Metabolic Syndrome.PloS one · 2015Article
- GM3 and diabetes.Glycoconjugate journal · 2014Review
- Ceramides and glucosylceramides are independent antagonists of insulin signaling.The Journal of biological chemistry · 2014Article
- Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs.PloS one · 2014Article
- Renal distribution of ganglioside GM3 in rat models of types 1 and 2 diabetes.Journal of physiology and biochemistry · 2013Article
- Human GM3 Synthase Attenuates Taxol-Triggered Apoptosis Associated with Downregulation of Caspase-3 in Ovarian Cancer Cells.Journal of cancer therapy · 2012Article
- Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3.Cancer science · 2012Article
- The hypothesis on function of glycosphingolipids and ABO blood groups revisited.Neurochemical research · 2012Review
- Lipidomics of glycosphingolipids.Metabolites · 2012Article
- Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.Chemical reviews · 2011Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since I was involved in the molecular cloning of GM3 synthase (SAT-I), which is the primary enzyme for the biosynthesis of gangliosides in 1998, my research group has been concentrating on our efforts to explore the physiological and pathological implications of gangliosides especially for GM3. During the course of study, we demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides in membrane microdomains and propose a new concept: Life style-related diseases, such as type 2 diabetes, are a membrane microdomain disorder caused by aberrant expression of gangliosides. We also encountered an another interesting aspect indicating the indispensable role of gangliosides in auditory system. After careful behavioral examinations of SAT-I knockout mice, their hearing ability was seriously impaired with selective degeneration of the stereocilia of hair cells in the organ of Corti. This is the first observation demonstrating a direct link between gangliosides and hearing functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.