ArticleJournal of lipid research2011
Genetic loci for blood lipid levels identified by linkage and association analyses in Caribbean Hispanics.
Article in Journal of lipid research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
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- The Genetics behind Sulfation: Impact on Airway Remodeling.Journal of personalized medicine · 2024Review
- Inclusion of endophenotypes in a standard GWAS facilitate a detailed mechanistic understanding of genetic elements that control blood lipid levels.Scientific reports · 2020Article
- Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.Nature communications · 2019Article
- Genome-Wide Studies of Type 2 Diabetes and Lipid Traits in Hispanics.Current diabetes reports · 2016Review
- Genetic susceptibility to cerebrovascular disease.Current opinion in lipidology · 2016Review
- Genetic variants in LEKR1 and GALNT10 modulate sex-difference in carotid intima-media thickness: a genome-wide interaction study.Atherosclerosis · 2015Article
- CDH13 promoter SNPs with pleiotropic effect on cardiometabolic parameters represent methylation QTLs.Human genetics · 2015Article
- Downregulation of SUMF2 gene in ovalbumin-induced rat model of allergic inflammation.International journal of clinical and experimental pathology · 2015Article
- Disruption of ldlr causes increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia.Journal of lipid research · 2014Article
- Genome-wide QTL mapping of nine body composition and bone mineral density traits in pigs.Genetics, selection, evolution : GSE · 2014Article
- Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics.Journal of the neurological sciences · 2014Article
- Cardiometabolic effects of adiponectin.Best practice & research. Clinical endocrinology & metabolism · 2014Review
- Association between CDH13 variants and cardiometabolic and vascular phenotypes in a Korean population.Yonsei medical journal · 2013Article
- T-cadherin is essential for adiponectin-mediated revascularization.The Journal of biological chemistry · 2013Article
- Genetic copy number variants in myocardial infarction patients with hyperlipidemia.BMC genomics · 2011Article
- A genome-wide association study of stroke risk in Asian statin users: evidence from KoGES and UK Biobank.PharmacogenomicsArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
To identify genetic loci influencing blood lipid levels in Caribbean Hispanics, we first conducted a genome-wide linkage scan in 1,211 subjects from 100 Dominican families on five lipid quantitative traits: total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), and LDL-C/HDL-C ratio. We then investigated the association between blood lipid levels and 21,361 single nucleotide polymorphisms (SNP) under the 1-logarithm of odds (LOD) unit down regions of linkage peaks in an independent community-based subcohort (N = 814, 42% Dominican) from the Northern Manhattan Study (NOMAS). We found significant linkage evidence for LDL-C/HDL-C on 7p12 (multipoint LOD = 3.91) and for TC on 16q23 (LOD = 3.35). In addition, we identified suggestive linkage evidence of LOD > 2.0 on 15q23 for TG, 16q23 for LDL-C, 19q12 for TC and LDL-C, and 20p12 for LDL-C. In the association analysis of the linkage peaks, we found that seven SNPs near FLJ45974 were associated with LDL-C/HDL-C with a nominal P < 3.5 × 10(-5), in addition to associations (P < 0.0001) for other lipid traits with SNPs in or near CDH13, SUMF2, TLE3, FAH, ARNT2, TSHZ3, ZNF343, RPL7AL2, and TMC3. Further studies are warranted to perform in-depth investigations of functional genetic variants in these regions.
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