ReviewAmerican journal of physiology. Endocrinology and metabolism2011
Skeletal muscle lipid flux: running water carries no poison.
Review in American journal of physiology. Endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Trial
- Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice.Life metabolism · 2023Article
- Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin.Antioxidants (Basel, Switzerland) · 2022Review
- Low lysophosphatidylcholine induces skeletal muscle myopathy that is aggravated by high-fat diet feeding.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Reign in the membrane: How common lipids govern mitochondrial function.Current opinion in cell biology · 2020Review
- Pharmacological inhibition of TLR4 ameliorates muscle and liver ceramide content after disuse in previously physically active mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Vitamin D produces a perilipin 2-dependent increase in mitochondrial function in C2C12 myotubes.The Journal of nutritional biochemistry · 2019Article
- Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques.Journal of lipid research · 2018Article
- Calcitriol concomitantly enhances insulin sensitivity and alters myocellular lipid partitioning in high fat-treated skeletal muscle cells.Journal of physiology and biochemistry · 2017Article
- Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria.Trends in endocrinology and metabolism: TEM · 2016Review
- Review
- Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function.Diabetes · 2016Article
- Citrus flavonoid, naringenin, increases locomotor activity and reduces diacylglycerol accumulation in skeletal muscle of obese ovariectomized mice.Molecular nutrition & food research · 2016Article
- Lipogenesis mitigates dysregulated sarcoplasmic reticulum calcium uptake in muscular dystrophy.Biochimica et biophysica acta · 2015Article
- Reduced efficiency of sarcolipin-dependent respiration in myocytes from humans with severe obesity.Obesity (Silver Spring, Md.) · 2015Article
- The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle.Skeletal muscle · 2015Article
- Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity.Diabetes · 2013Article
- SCD1 activity in muscle increases triglyceride PUFA content, exercise capacity, and PPARδ expression in mice.Journal of lipid research · 2013Article
- Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice.Endocrinology · 2013Article
- Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling.The Journal of clinical investigation · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Lipids are the most abundant organic constituents in many humans. The rise in obesity prevalence has prompted a need for a more refined understanding of the effects of lipid molecules on cell physiology. In skeletal muscle, deposition of lipids can be associated with insulin resistance that contributes to the development of diabetes. Here, we review the evidence that muscle cells are equipped with the molecular machinery to convert and sequester lipid molecules, thus rendering them harmless. Induction of mitochondrial and lipogenic flux in the setting of elevated lipid deposition can protect muscle from lipid-induced "poisoning" of the cellular machinery. Lipid flux may also be directed toward the synthesis of ligands for nuclear receptors, further enhancing the capacity of muscle for lipid metabolism to promote favorable physiology. Exploiting these mechanisms may have implications for the treatment of obesity-related diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.