ArticleThe Plant cell2011
DOLICHOL PHOSPHATE MANNOSE SYNTHASE1 mediates the biogenesis of isoprenyl-linked glycans and influences development, stress response, and ammonium hypersensitivity in Arabidopsis.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Identification of poplar and spruce GDP-mannose pyrophosphorylases involved in mannan and ascorbic acid biosynthesis.Tree physiology · 2026Article
- Repurposing the HMG-CoA reductase inhibitor atorvastatin for SRD5A3-congenital disorder of glycosylation.Communications medicine · 2026Article
- Mysterious giants in the world of lipids: long linear isoprenoid functions in plant physiology and reproduction.Journal of experimental botany · 2026Review
- Phenotype Assessment and Putative Mechanisms of Ammonium Toxicity to Plants.International journal of molecular sciences · 2025Review
- Ion toxicity in waterlogged soils: mechanisms of root response and adaptive strategies.Frontiers in plant science · 2025Review
- Deciphering the Mechanism of Tolerance to Apple Replant Disease Using a Genetic Mapping Approach in a Malling 9 ×International journal of molecular sciences · 2023Article
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- Sweet Modifications Modulate Plant Development.Biomolecules · 2021Review
- A Pipeline towards the Biochemical Characterization of theInternational journal of molecular sciences · 2021Article
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- Internal ammonium excess induces ROS-mediated reactions and causes carbon scarcity in rice.BMC plant biology · 2020Article
- Article
- Effect of Salt and Fresh Water Concentration on Polyisoprenoid Content inOpen access Macedonian journal of medical sciences · 2019Article
- Molecular Characterisation of a Supergene Conditioning Super-High Vitamin C in Kiwifruit Hybrids.Plants (Basel, Switzerland) · 2019Article
- The Arabidopsis AMOT1/EIN3 gene plays an important role in the amelioration of ammonium toxicity.Journal of experimental botany · 2019Article
- Dolichol phosphate mannose synthase: a Glycosyltransferase with Unity in molecular diversities.Glycoconjugate journal · 2017Review
- The Arabidopsis Golgi-localized GDP-L-fucose transporter is required for plant development.Nature communications · 2016Article
- POLYPRENOL REDUCTASE2 Deficiency Is Lethal in Arabidopsis Due to Male Sterility.The Plant cell · 2015Article
- Identification and characterization of Arabidopsis AtNUDX9 as a GDP-d-mannose pyrophosphohydrolase: its involvement in root growth inhibition in response to ammonium.Journal of experimental botany · 2015Article
- Mild ammonium stress increases chlorophyll content in Arabidopsis thaliana.Plant signaling & behavior · 2015Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most abundant posttranslational modification in nature is the attachment of preassembled high-mannose-type glycans, which determines the fate and localization of the modified protein and modulates the biological functions of glycosylphosphatidylinositol-anchored and N-glycosylated proteins. In eukaryotes, all mannose residues attached to glycoproteins from the luminal side of the endoplasmic reticulum (ER) derive from the polyprenyl monosaccharide carrier, dolichol P-mannose (Dol-P-Man), which is flipped across the ER membrane to the lumen. We show that in plants, Dol-P-Man is synthesized when Dol-P-Man synthase1 (DPMS1), the catalytic core, interacts with two binding proteins, DPMS2 and DPMS3, that may serve as membrane anchors for DPMS1 or provide catalytic assistance. This configuration is reminiscent of that observed in mammals but is distinct from the single DPMS protein catalyzing Dol-P-Man biosynthesis in bakers' yeast and protozoan parasites. Overexpression of DPMS1 in Arabidopsis thaliana results in disorganized stem morphology and vascular bundle arrangements, wrinkled seed coat, and constitutive ER stress response. Loss-of-function mutations and RNA interference-mediated reduction of DPMS1 expression in Arabidopsis also caused a wrinkled seed coat phenotype and most remarkably enhanced hypersensitivity to ammonium that was manifested by extensive chlorosis and a strong reduction of root growth. Collectively, these data reveal a previously unsuspected role of the prenyl-linked carrier pathway for plant development and physiology that may help integrate several aspects of candidate susceptibility genes to ammonium stress.
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