ArticleDevelopment (Cambridge, England)2011
The actin nucleator WASp is required for myoblast fusion during adult Drosophila myogenesis.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Signalling networks orchestrating the development of Drosophila indirect flight muscles.Histochemistry and cell biology · 2026Review
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- Reduced Wiskott-Aldrich syndrome protein expression in preeclampsia placenta impairs trophoblast syncytialization by modulating syncytin-2 via FAK/β-catenin pathway.Frontiers in cell and developmental biology · 2025Article
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- Ral function in muscle is required for flight maintenance inSmall GTPases · 2020Article
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- The fusogenic synapse at a glance.Journal of cell science · 2019Review
- Escort cell encapsulation ofBiology open · 2019Article
- Acting on identity: Myoblast fusion and the formation of the syncytial muscle fiber.Seminars in cell & developmental biology · 2017Review
- Live Imaging of Myogenesis in Indirect Flight Muscles inBio-protocol · 2017Article
- Adult Muscle Formation RequiresGenetics · 2017Article
- Surface apposition and multiple cell contacts promote myoblast fusion in Drosophila flight muscles.The Journal of cell biology · 2015Article
- Mechanisms of myoblast fusion during muscle development.Current opinion in genetics & development · 2015Review
- Identification of singles bar as a direct transcriptional target of Drosophila Myocyte enhancer factor-2 and a regulator of adult myoblast fusion.Developmental biology · 2015Article
- Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms.Cytoskeleton (Hoboken, N.J.) · 2015Review
- A Tendon Cell Specific RNAi Screen Reveals Novel Candidates Essential for Muscle Tendon Interaction.PloS one · 2015Article
- The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila.Journal of cell science · 2014Article
- PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site.Development (Cambridge, England) · 2014Article
- Whole-mount immunostaining of Drosophila skeletal muscle.Nature protocols · 2013Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Myoblast fusion provides a fundamental, conserved mechanism for muscle fiber growth. We demonstrate here that the functional contribution of Wsp, the Drosophila homolog of the conserved actin nucleation-promoting factor (NPF) WASp, is essential for myoblast fusion during the formation of muscles of the adult fly. Disruption of Wsp function results in complete arrest of myoblast fusion in all muscles examined. Wsp activity during adult Drosophila myogenesis is specifically required for muscle cell fusion and is crucial both for the formation of new muscle fibers and for the growth of muscles derived from persistent larval templates. Although Wsp is expressed both in fibers and individual myoblasts, its activity in either one of these cell types is sufficient. SCAR, a second major Arp2/3 NPF, is also required during adult myoblast fusion. Formation of fusion-associated actin 'foci' is dependent on Arp2/3 complex function, but appears to rely on a distinct, unknown nucleator. The comprehensive nature of these requirements identifies Arp2/3-based branched actin polymerization as a universal mechanism underlying myoblast fusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.