ArticleDevelopment (Cambridge, England)2011
Coordinated expression of cell death genes regulates neuroblast apoptosis.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 61 citations in OpenAlex.
- AlphaFold3-based modeling uncovers the dynamic structural interface between full-length IAP antagonists and DIAP1 for apoptosis regulation in Drosophila.Cell communication and signaling : CCS · 2026Article
- Casein kinase 2 maintains the self-renewal of neural stem cells via prospero phosphorylation in Drosophila.Cell & bioscience · 2026Article
- The Hox Gene,Molecular biology of the cell · 2025Article
- The Hox Gene,bioRxiv : the preprint server for biology · 2025Article
- Plastic Fly: WhatInternational journal of molecular sciences · 2024Article
- Article
- Hunchback prevents notch-induced apoptosis in the serotonergic lineage of Drosophila Melanogaster.Developmental biology · 2022Article
- Sequential activation of Notch and Grainyhead gives apoptotic competence to Abdominal-B expressing larval neuroblasts in Drosophila Central nervous system.PLoS genetics · 2020Article
- Decoupling developmental apoptosis and neuroblast proliferation in Drosophila.Developmental biology · 2019Article
- Review
- The Hox geneDevelopment (Cambridge, England) · 2019Article
- Comparative Identification of MicroRNAs inInsects · 2019Article
- A Cut/cohesin axis alters the chromatin landscape to facilitate neuroblast death.Development (Cambridge, England) · 2019Article
- P53 and Apoptosis in the Drosophila Model.Advances in experimental medicine and biology · 2019Review
- I Spy in the Developing Fly a Multitude of Ways to Die.Journal of developmental biology · 2018Review
- Drosophila as a Model for Developmental Biology: Stem Cell-Fate Decisions in the Developing Nervous System.Journal of developmental biology · 2018Review
- Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity inThe EMBO journal · 2018Article
- Combinatorial action of Grainyhead, Extradenticle and Notch in regulating Hox mediated apoptosis in Drosophila larval CNS.PLoS genetics · 2017Article
- Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system.FEBS letters · 2016Review
- Cell death regulates muscle fiber number.Developmental biology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Properly regulated apoptosis in the developing central nervous system is crucial for normal morphogenesis and homeostasis. In Drosophila, a subset of neural stem cells, or neuroblasts, undergo apoptosis during embryogenesis. Of the 30 neuroblasts initially present in each abdominal hemisegment of the embryonic ventral nerve cord, only three survive into larval life, and these undergo apoptosis in the larvae. Here, we use loss-of-function analysis to demonstrate that neuroblast apoptosis during embryogenesis requires the coordinated expression of the cell death genes grim and reaper, and possibly sickle. These genes are clustered in a 140 kb region of the third chromosome and show overlapping patterns of expression. We show that expression of grim, reaper and sickle in embryonic neuroblasts is controlled by a common regulatory region located between reaper and grim. In the absence of grim and reaper, many neuroblasts survive the embryonic period of cell death and the ventral nerve cord becomes massively hypertrophic. Deletion of grim alone blocks the death of neuroblasts in the larvae. The overlapping activity of these multiple cell death genes suggests that the coordinated regulation of their expression provides flexibility in this crucial developmental process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.