ArticleDevelopment (Cambridge, England)2011
Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Intrinsic apoptosis is evolutionarily divergent among metazoans.Evolution letters · 2024Article
- Non-Apoptotic Role of Apoptotic Caspases in theFrontiers in cell and developmental biology · 2022Review
- Non-apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence.EMBO reports · 2020Article
- Novel initiator caspase reporters uncover previously unknown features of caspase-activating cells.Development (Cambridge, England) · 2018Article
- Non-apoptotic Caspase regulation of stem cell properties.Seminars in cell & developmental biology · 2018Review
- Learning on the Fly: The Interplay between Caspases and Cancer.BioMed research international · 2018Review
- p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis.PLoS genetics · 2017Article
- The bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brain.PLoS genetics · 2017Article
- Controlling caspase activity in life and death.PLoS genetics · 2017Article
- Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours inBioMed research international · 2017Article
- Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca(2+) Homeostasis in Neural Stem Cell Development.Developmental cell · 2016Article
- Drosophila neuroblasts as a new model for the study of stem cell self-renewal and tumour formation.Bioscience reports · 2014Review
- The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB.The Journal of cell biology · 2014Article
- The role of apoptosis-induced proliferation for regeneration and cancer.Cold Spring Harbor perspectives in biology · 2012Review
- Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells.The Journal of biological chemistry · 2012Article
- Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis.Developmental biology · 2012Article
- Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Drosophila neuroblasts have served as a model to understand how the balance of stem cell self-renewal versus differentiation is achieved. Drosophila Numb protein regulates this process through its preferential segregation into the differentiating daughter cell. How Numb restricts the proliferation and self-renewal potentials of the recipient cell remains enigmatic. Here, we show that phosphorylation at conserved sites regulates the tumor suppressor activity of Numb. Enforced expression of a phospho-mimetic form of Numb (Numb-TS4D) or genetic manipulation that boosts phospho-Numb levels, attenuates endogenous Numb activity and causes ectopic neuroblast formation (ENF). This effect on neuroblast homeostasis occurs only in the type II neuroblast lineage. We identify Dronc caspase as a novel binding partner of Numb, and demonstrate that overexpression of Dronc suppresses the effects of Numb-TS4D in a non-apoptotic and possibly non-catalytic manner. Reduction of Dronc activity facilitates ENF induced by phospho-Numb. Our findings uncover a molecular mechanism that regulates Numb activity and suggest a novel role for Dronc caspase in regulating neural stem cell homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.