ArticleBritish journal of clinical pharmacology2011
The effect of selective serotonin re-uptake inhibitors on the risk of myocardial infarction in a cohort of patients with depression.
Article in British journal of clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Use of antidepressants and the risk of cardiovascular and cerebrovascular disease: a meta-analysis of observational studies.European journal of clinical pharmacology · 2017Pooled it
- Antidepressant use and risk of coronary heart disease: meta-analysis of observational studies.British journal of clinical pharmacology · 2014Pooled it
- Impact of antidepressants use on risk of myocardial infarction: A systematic review and meta-analysis.Indian journal of pharmacologyPooled it
- Psychological Distress and Cognitive Function in Women: Exploring Potential Mediation by Use of Opiates, Sleep Aids, or Minor Tranquilizers.Journal of women's health (2002) · 2025Article
- The association between the fluoxetine use and the occurrence of coronary heart disease: a nationwide retrospective cohort study.BMC cardiovascular disorders · 2024Article
- Sertraline in depressed patients with or at risk for coronary heart disese: a systemic review.American journal of cardiovascular disease · 2024Review
- Exploring the Heart-Mind Connection: Unraveling the Shared Pathways between Depression and Cardiovascular Diseases.Biomedicines · 2023Review
- Serotonin: a platelet hormone modulating cardiovascular disease.Journal of thrombosis and thrombolysis · 2021Review
- Psychiatric and Psychological Interventions for Depression in Patients With Heart Disease: A Scoping Review.Journal of the American Heart Association · 2020Article
- Endothelial dysfunction in neuroprogressive disorders-causes and suggested treatments.BMC medicine · 2020Review
- Differential effects of antidepressant subgroups on risk of acute myocardial infarction: A nested case-control study.British journal of clinical pharmacology · 2020Article
- Peripheral microvascular serotoninergic signaling is dysregulated in young adults with major depressive disorder.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Using human experience to identify drug repurposing opportunities: theory and practice.British journal of clinical pharmacology · 2019Review
- Anxiety Disorders and Cardiovascular Disease.Current psychiatry reports · 2016Review
- Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: cohort study using primary care database.BMJ (Clinical research ed.) · 2016Observational
- Use of antidepressants and the risk of myocardial infarction in middle-aged and older adults: a matched case-control study.European journal of clinical pharmacology · 2016Article
- Functional constituents of a local serotonergic system, intrinsic to the human coronary artery smooth muscle cells.Molecular biology reports · 2015Article
- Risk of gastrointestinal bleeding and cardiovascular events due to NSAIDs in the diabetic elderly population.BMJ open diabetes research & care · 2015Article
- Central nervous system circuits modified in heart failure: pathophysiology and therapeutic implications.Heart failure reviews · 2014Review
- Selective serotonin reuptake inhibitors and endothelial function in women.Journal of women's health (2002) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate whether selective serotonin re-uptake inhibitor (SSRI) exposure influences the risk of myocardial infarction (MI) in patients with depression.
methodsThis study included 693 patients with MI (cases) and 2772 controls. Conditional logistic regression was used to calculate the odds ratio (OR).
resultsSSRI exposure may be associated with a reduced MI risk (OR = 0.77, 95% CI 0.57, 1.03). However, reduced risk was only observed with longer term use (OR = 0.73, 95% CI 0.53, 1.00) and not with shorter term use (OR = 1.15, 95% CI: 0.65, 2.05).
conclusionsOnly longer term use of SSRIs was associated with reduced MI risk, suggesting that other mechanisms, besides an acute anti-platelet effect, may reduce MI risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.