ReviewDevelopmental neurobiology2012
Neurotransmitter phenotype plasticity: an unexpected mechanism in the toolbox of network activity homeostasis.
Review in Developmental neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Chemical multiplexing in the nervous system: molecular architecture, functional stratification, and pathophysiological plasticity of neuropeptide-classical neurotransmitter cotransmission.Frontiers in molecular neuroscience · 2026Review
- Molecular Determinants of A9 Dopaminergic Neurons.Neuromolecular medicine · 2025Review
- Socially induced plasticity of the posterior tuberculum and motor behavior in zebrafish (Danio rerio).The Journal of experimental biology · 2024Article
- Homologous vs. homocratic neurons: revisiting complex evolutionary trajectories.Frontiers in cell and developmental biology · 2023Article
- High-frequency stimulation of the subthalamic nucleus induces a sustained inhibition of serotonergic system via loss of cell phenotype.Scientific reports · 2022Article
- Neuronal Trans-differentiation by Transcription Factors Ascl1 and Nurr1: Induction of a Dopaminergic Neurotransmitter Phenotype in Cortical GABAergic Neurons.Molecular neurobiology · 2020Article
- Article
- Modulation of Neocortical Development by Early Neuronal Activity: Physiology and Pathophysiology.Frontiers in cellular neuroscience · 2017Review
- Cellular architecture and transmitter phenotypes of neurons of the mouse median raphe region.Brain structure & function · 2017Article
- Changes in neurochemicals within the ventrolateral medullary respiratory column in awake goats after carotid body denervation.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs.Molecular brain · 2013Article
- Large-scale synchronized activity in the embryonic brainstem and spinal cord.Frontiers in cellular neuroscience · 2013Article
- Hierarchical clustering of gene expression patterns in the Eomes + lineage of excitatory neurons during early neocortical development.BMC neuroscience · 2012Article
- Activity-dependent alternative splicing increases persistent sodium current and promotes seizure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Temporally tuned neuronal differentiation supports the functional remodeling of a neuronal network in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Plasticity of the myelination genomic fabric.Molecular genetics and genomics : MGG · 2012Article
- Activity-dependent neurotransmitter respecification.Nature reviews. Neuroscience · 2012Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The transmitter phenotype of a neuron has long been thought to be stable for the lifespan. Much as eyes have one color and do not change it over time, neurons have been thought to have one neurotransmitter and retain it for their lifetime. Both principles, exclusivity and stability, are challenged by recent data. More and more neurons in different regions of the brain appear to coexpress two or more neurotransmitters. Moreover, the profile of neurotransmitter expression of a given neuron has been shown to change over time, both during development and in response to changes in activity. The present review summarizes recent studies of this neurotransmitter phenotype plasticity (NPP). Homeostatic mechanisms of plasticity are aimed at maintaining the system within a functional range. They appear to be critical for optimal network operations and have been thought to operate largely by regulating intrinsic excitability, synapse number and synaptic strength. NPP provides a new and unexpected level of regulation of network homeostasis. We propose that it provides the basis for NT coexpression and discuss emerging issues and new questions for further studies in coming years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.