ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2011
Common genetic influences on depression, alcohol, and substance use disorders in Mexican-American families.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.Nature medicine · 2023Pooled it
- Co-alteration Network Architecture of Major Depressive Disorder: A Multi-modal Neuroimaging Assessment of Large-scale Disease Effects.Neuroinformatics · 2023Pooled it
- Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion inCirculation. Genomic and precision medicine · 2021Trial
- Psychiatric genetics in the diverse landscape of Latin American populations.Nature genetics · 2025Review
- Substance Use-Related Factors and Recurrent Depression among Former Adolescent Psychiatric Inpatients.European addiction research · 2025Article
- Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water.Human brain mapping · 2025Article
- Imputation of plasma lipid species to facilitate integration of lipidomic datasets.Nature communications · 2024Article
- Cocktail-party listening and cognitive abilities show strong pleiotropy.Frontiers in neurology · 2023Article
- Polysubstance Use, Mood Disorders, and Chronic Conditions With Anxiety in Opioid Patients.Western journal of nursing research · 2022Article
- Article
- Familial co-aggregation and shared heritability between depression, anxiety, obesity and substance use.Translational psychiatry · 2022Article
- Influence of the Human Lipidome on Epicardial Fat Volume in Mexican American Individuals.Frontiers in cardiovascular medicine · 2022Article
- Association of HIV-1 Infection and Antiretroviral Therapy With Type 2 Diabetes in the Hispanic Population of the Rio Grande Valley, Texas, USA.Frontiers in medicine · 2021Article
- The reliability and heritability of cortical folds and their genetic correlations across hemispheres.Communications biology · 2020Article
- Neurocognitive impairment in type 2 diabetes: evidence for shared genetic aetiology.Diabetologia · 2020Article
- ANRIL Variants Are Associated with Risk of Neuropsychiatric Conditions.Journal of molecular neuroscience : MN · 2020Article
- A Review of Mental Health and Mental Health Care Disparities Research: 2011-2014.Medical care research and review : MCRR · 2019Review
- The Penrose Effect and its acceleration by the war on drugs: a crisis of untranslated neuroscience and untreated addiction and mental illness.Translational psychiatry · 2019Review
- Evidence for genetic correlation between human cerebral white matter microstructure and inflammation.Human brain mapping · 2019Article
- RareJournal of lipid research · 2019Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Multiple genetic and environmental factors influence the risk for both major depression and alcohol/substance use disorders. In addition, there is evidence that these illnesses share genetic factors. Although, the heritability of these illnesses is well established, relatively few studies have focused on ethnic minority populations. Here, we document the prevalence, heritability, and genetic correlations between major depression and alcohol and drug disorders in a large, community-ascertained sample of Mexican-American families. A total of 1,122 Mexican-American individuals from 71 extended pedigrees participated in the study. All subjects received in-person psychiatric interviews. Heritability, genetic, and environmental correlations were estimated using SOLAR. Thirty-five percent of the sample met criteria for DSM-IV lifetime major depression, 34% met lifetime criteria for alcohol use disorders, and 8% met criteria for lifetime drug use disorders. The heritability for major depression was estimated to be h(2) = 0.393 (P = 3.7 × 10(-6)). Heritability estimates were higher for recurrent depression (h(2) = 0.463, P = 4.0 × 10(-6)) and early onset depression (h(2) = 0.485, P = 8.5 × 10(-5)). While the genetic correlation between major depression and alcohol use disorders was significant (ρ(g) = 0.58, P = 7 × 10(-3)), the environmental correlation between these traits was not significant. Although, there is evidence for increased rates of depression and substance use in US-born individuals of Mexican ancestry, our findings indicate that genetic control over major depression and alcohol/substance use disorders in the Mexican-American population is similar to that reported in other populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.