ArticleMedical & biological engineering & computing2011
Computational analysis of nanoparticle adhesion to endothelium: effects of kinetic rate constants and wall shear rates.
Article in Medical & biological engineering & computing, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Multiscale physics-basedFrontiers in drug delivery · 2024Review
- Rotating Magnetic Nanoparticle Clusters as Microdevices for Drug Delivery.International journal of nanomedicine · 2020Article
- Evaluation of Receptor-Ligand Mechanisms of Dual-Targeted Particles to an Inflamed Endothelium.Bioengineering & translational medicine · 2016Article
- Organ-on-a-chip platforms for studying drug delivery systems.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Novel automated tracking analysis of particles subjected to shear flow: kindlin-3 role in B cells.Biophysical journal · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various nanoparticles have been developed as imaging probes and drug carriers, and their selectivity in binding to target cells determines the efficacy of these functionalized nanoparticles. Since target cells in different arterial segments experience different hemodynamic environments, we study the effects of wall shear rate waveforms on particle binding. We also explore the effects of the kinetic rate constant, which is determined by particle design parameters, on particle binding. A transport and reaction model is used to evaluate nanoparticle binding to the substrate in a laminar flow chamber. Flow and particle concentration fields are solved by using a computational fluid dynamics. The particle binding rate increases as the mean value of wall shear increases, and the amplitudes of sinusoidal shear waveform do not affect the bound particle density profiles significantly. Particle binding rates increase with the rate constant of attachment (k(A)), and are more sensitively affected by low k(A) values and less by k(A) values higher than 1 × 10⁻⁶ m s⁻¹. Since binding selectivity is affected by k(A) and the wall shear rate, the results of this study can be used for designing functionalized nanoparticles targeting for the specific cells that experience a specific shear rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.