ArticleImmunogenetics2011
Screening and confirmatory testing of MHC class I alleles in pig-tailed macaques.
Article in Immunogenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect.The Journal of experimental medicine · 2026Article
- HIV-1 and drug abuse comorbidity: Lessons learned from the animal models of NeuroHIV.Neuroscience letters · 2021Review
- Development and evaluation of a rapid and cost-efficient NGS-based MHC class I genotyping method for macaques by using a prevalent short-read sequencer.Immunogenetics · 2021Article
- MHC class I diversity of olive baboons (Papio anubis) unravelled by next-generation sequencing.Immunogenetics · 2018Article
- Novel full-length major histocompatibility complex class I allele discovery and haplotype definition in pig-tailed macaques.Immunogenetics · 2018Article
- Genome-wide mining and comparative analysis of microsatellites in three macaque species.Molecular genetics and genomics : MGG · 2017Article
- Comparative genomics of the human, macaque and mouse major histocompatibility complex.Immunology · 2017Review
- Central nervous system-specific consequences of simian immunodeficiency virus Gag escape from major histocompatibility complex class I-mediated control.Journal of neurovirology · 2016Article
- Novel MHC class I full-length allele and haplotype characterization in sooty mangabeys.Immunogenetics · 2015Article
- Simian immunodeficiency virus infection and immune responses in the pig-tailed macaque testis.Journal of leukocyte biology · 2015Article
- Linking pig-tailed macaque major histocompatibility complex class I haplotypes and cytotoxic T lymphocyte escape mutations in simian immunodeficiency virus infection.Journal of virology · 2014Article
- Survey of major histocompatibility complex class II diversity in pig-tailed macaques.Immunogenetics · 2014Article
- Full-length novel MHC class I allele discovery by next-generation sequencing: two platforms are better than one.Immunogenetics · 2014Article
- Standard trivalent influenza virus protein vaccination does not prime antibody-dependent cellular cytotoxicity in macaques.Journal of virology · 2013Article
- Identification of MHC class I sequences in four species of Macaca of China.Immunogenetics · 2013Article
- In-vivo stimulation of macaque natural killer T cells with α-galactosylceramide.Clinical and experimental immunology · 2013Article
- Major histocompatibility complex class I haplotype diversity in Chinese rhesus macaques.G3 (Bethesda, Md.) · 2013Article
- Antibody-dependent cellular cytotoxicity is associated with control of pandemic H1N1 influenza virus infection of macaques.Journal of virology · 2013Article
- Trivalent live attenuated influenza-simian immunodeficiency virus vaccines: efficacy and evolution of cytotoxic T lymphocyte escape in macaques.Journal of virology · 2013Article
- Haplessly hoping: macaque major histocompatibility complex made easy.ILAR journal · 2013Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Pig-tailed macaques (Macaca nemestrina) are a commonly studied primate model of human AIDS. The Mane-A1*084:01 MHC class I allele (previously named Mane-A*10) is important for the control of SIV infection by CD8+ T cells in this model. Validated methods to detect this allele in large numbers of macaques are lacking. We studied this MHC allele using sequence-specific PCRs in 217 pig-tailed macaques and identified 75 (35%) positive animals. We then performed massively parallel pyrosequencing with a universal 568-bp MHC class I cDNA-PCR amplicon for 50 of these 75 macaques. All 50 animals expressed Mane-A1*084:01 or closely related variants of the Mane-A1*084 lineage. Mane-A1*084 transcripts accounted for an average of 20.9% of all class I sequences identified per animal. SIV infection of a subset of these macaques resulted in the induction of SIV-specific CD8+ T cell responses detected by Mane-A1*084:01 tetramers. An average of 19 distinct class I transcripts were identified per animal by pyrosequencing. This analysis revealed 89 new Mane class I sequences as well as 32 previously described sequences that were extended with the longer amplicons employed in the current study. In addition, multiple Mane class I haplotypes that had been inferred previously based on shared transcript profiles between unrelated animals were confirmed for a subset of animals where pedigree information was available. We conclude that sequence-specific PCR is useful to screen pig-tailed macaques for Mane-A1*084:01, although pyrosequencing permits a much broader identification of the repertoire of MHC class I sequences and haplotypes expressed by individual animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.