ArticleDevelopment genes and evolution2011
A novel tissue in an established model system: the Drosophila pupal midgut.
Article in Development genes and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Intrinsic regulation of intestinal stem cell fate and homeostasis by Tet.bioRxiv : the preprint server for biology · 2026Article
- Establishment of Drosophila intestinal cell lines as tools for multiomic screening and deciphering intestinal biology.Scientific reports · 2025Article
- Age mosaic of gut epithelial cells prevents aging.Nature communications · 2025Article
- Microbiome composition and turnover in the face of complex lifecycles and bottlenecks: insights through the study of dung beetles.Applied and environmental microbiology · 2025Article
- The emergence of circadian timekeeping in the intestine.Nature communications · 2024Article
- Understanding Developmental Cell Death UsingCells · 2024Review
- Article
- Gut barrier defects, intestinal immune hyperactivation and enhanced lipid catabolism drive lethality in NGLY1-deficient Drosophila.Nature communications · 2023Article
- Gut bacterial population and community dynamics following adult emergence in pest tephritid fruit flies.Scientific reports · 2023Article
- Protein- and Carbohydrate-Rich Supplements in Feeding Adult Black Soldier Flies (Life (Basel, Switzerland) · 2023Article
- Epithelial Cell Polarity DuringFrontiers in cell and developmental biology · 2022Review
- Commensal microbiota-induced redox signaling activates proliferative signals in the intestinal stem cell microenvironment.Development (Cambridge, England) · 2019Article
- More diversity in epithelial cell polarity: A fruit flies' gut feeling.PLoS biology · 2018Article
- Anatomy and Physiology of the Digestive Tract ofGenetics · 2018Review
- The effect of gut microbiota elimination inEcology and evolution · 2018Article
- Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective.Journal of developmental biology · 2018Review
- Mitochondrial dynamics regulates Drosophila intestinal stem cell differentiation.Cell death discovery · 2018Article
- bHLH proneural genes as cell fate determinants of entero-endocrine cells, an evolutionarily conserved lineage sharing a common root with sensory neurons.Developmental biology · 2017Article
- Looking into the puparium: Micro-CT visualization of the internal morphological changes during metamorphosis of the blow fly, Calliphora vicina, with the first quantitative analysis of organ development in cyclorrhaphous dipterans.Journal of morphology · 2017Article
- Metamorphosis of the Drosophila visceral musculature and its role in intestinal morphogenesis and stem cell formation.Developmental biology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The Drosophila larval and adult midguts are derived from two populations of endodermal progenitors that separate from each other in the early embryo. As larval midgut cells differentiate into an epithelial layer, adult midgut progenitors (AMPs) remain as small clusters of proliferating, undifferentiated cells attached to the basal surface of the larval gut epithelium. During the first few hours of metamorphosis, AMPs merge into a continuous epithelial tube that overgrows the larval layer and differentiates into the adult midgut; at the same time, the larval midgut degenerates. As shown in this paper, there is a second, transient pupal midgut that develops from the AMPs at the beginning of metamorphosis and that intercalates between the adult and larval midgut epithelia. Cells of the transient pupal midgut form a multilayered tube that exhibits signs of differentiation, in the form of septate junctions and rudimentary apical microvilli. Some cells of the pupal midgut develop as endocrine cells. The pupal midgut remains closely attached to the degenerating larval midgut cells. Along with these cells, pupal midgut cells are sequestered into the lumen where they form the compact "yellow body." The formation of a pupal midgut has been reported from several other species and may represent a general feature of intestinal metamorphosis in insects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.