ArticleBrain structure & function2011
Projections from the rat pedunculopontine and laterodorsal tegmental nuclei to the anterior thalamus and ventral tegmental area arise from largely separate populations of neurons.
Article in Brain structure & function, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 68 citations in OpenAlex.
- The Acetylcholine Esterase Inhibitor Donepezil Increases Dopamine Levels in the Nucleus Accumbens and Blocks the Alcohol Deprivation Effect in Rats.Addiction biology · 2026Article
- Nicotine Withdrawal Drives Aversive Behaviors by Recruiting Inhibitory Interpeduncular Nucleus Inputs to the Laterodorsal Tegmentum in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders.Annual review of pharmacology and toxicology · 2024Review
- Neurochemistry of the mammillary body.Brain structure & function · 2023Review
- Prenatal nicotine alters development of the laterodorsal tegmentum: Possible role for attention-deficit/hyperactivity disorder and drug dependence.World journal of psychiatry · 2022Review
- Functional Interaction Between GABAergic Neurons in the Ventral Tegmental Area and Serotonergic Neurons in the Dorsal Raphe Nucleus.Frontiers in neuroscience · 2022Article
- Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals.Journal of neuroscience research · 2021Article
- GLP-1 receptor signaling in the laterodorsal tegmental nucleus attenuates cocaine seeking by activating GABAergic circuits that project to the VTA.Molecular psychiatry · 2021Article
- CaMKII antagonism in the ventral tegmental area impairs acquisition of conditioned approach learning in rats.Neurobiology of learning and memory · 2020Article
- Regional vesicular acetylcholine transporter distribution in human brain: A [The Journal of comparative neurology · 2018Article
- Activation of mesolimbic reward system via laterodorsal tegmental nucleus and hypothalamus in exercise-induced hypoalgesia.Scientific reports · 2018Article
- Critical appraisal of pathology transmission in the α-synuclein fibril model of Lewy body disorders.Experimental neurology · 2018Article
- Neurochemistry of the Anterior Thalamic Nuclei.Molecular neurobiology · 2017Review
- Activation of Pedunculopontine Glutamate Neurons Is Reinforcing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Pontomesencephalic Tegmental Afferents to VTA Non-dopamine Neurons Are Necessary for Appetitive Pavlovian Learning.Cell reports · 2016Article
- Ethanol-Induced Motor Impairment Mediated by Inhibition of α7 Nicotinic Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Pedunculopontine tegmental nucleus lesions impair probabilistic reversal learning by reducing sensitivity to positive reward feedback.Neurobiology of learning and memory · 2016Article
- Extrinsic Sources of Cholinergic Innervation of the Striatal Complex: A Whole-Brain Mapping Analysis.Frontiers in neuroanatomy · 2016Article
- Modeling Parkinson's disease falls associated with brainstem cholinergic systems decline.Behavioral neuroscience · 2015Article
- Intra-ventral tegmental area microinjections of urotensin II modulate the effects of cocaine.Behavioural brain research · 2015Article
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2 authors at 2 institutions in 1 country.
Funding
Abstract
Cholinergic and non-cholinergic neurons in the brainstem pedunculopontine (PPT) and laterodorsal tegmental (LDT) nuclei innervate diverse forebrain structures. The cholinergic neurons within these regions send heavy projections to thalamic nuclei and provide modulatory input as well to midbrain dopamine cells in the ventral tegmental area (VTA). Cholinergic PPT/LDT neurons are known to send collateralized projections to thalamic and non-thalamic targets, and previous studies have shown that many of the afferents to the VTA arise from neurons that also project to midline and intralaminar thalamic nuclei. However, whether cholinergic projections to the VTA and anterior thalamus (AT) are similarly collateralized is unknown. Ultrastructural work from our laboratory has demonstrated that cholinergic axon varicosities in these regions differ both morphologically and with respect to the expression and localization of the high-affinity choline transporter. We therefore hypothesized that the cholinergic innervation to these regions is provided by separate sets of PPT/LDT neurons. Dual retrograde tract-tracing from the AT and VTA indicated that only a small percentage of the total afferent population to either region showed evidence of providing collateralized input to the other target. Cholinergic and non-cholinergic cells displayed a similarly low percentage of collateralization. These results are contrasted to a control case in which retrograde labeling from the midline paratenial thalamic nucleus and the VTA resulted in higher percentages of cholinergic and non-cholinergic dual-tracer labeled cells. Our results indicate that functionally distinct limbic target regions receive primarily segregated signaling from PPT/LDT neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.