ArticleMolecular biology reports2012
Type 17 T-helper cells might be a promising therapeutic target for osteoporosis.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Transcriptomic Analysis Reveals PACS1 as a Potential Shared Candidate Biomarker for Apical Periodontitis and Osteoporosis.International journal of molecular sciences · 2026Article
- Immune cell profiles and predictive modeling in osteoporotic vertebral fractures using XGBoost machine learning algorithms.BioData mining · 2025Article
- Interleukin-10-Producing B Cells Help Suppress Ovariectomy-Mediated Osteoporosis.Immune network · 2020Article
- Polymorphisms in key bone modulator cytokines genes influence bisphosphonates therapy in postmenopausal women.Inflammopharmacology · 2017Article
- Gorham-Stout Disease: a Clinical Case Report and Immunological Mechanisms in Bone Erosion.Clinical reviews in allergy & immunology · 2017Review
- Bone disease in cystic fibrosis: new pathogenic insights opening novel therapies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Review
- Osteoporosis: the current status of mesenchymal stem cell-based therapy.Cellular & molecular biology letters · 2016Review
- The role of "bone immunological niche" for a new pathogenetic paradigm of osteoporosis.Analytical cellular pathology (Amsterdam) · 2015Review
- Th17 and Treg cells in bone related diseases.Clinical & developmental immunology · 2013Review
- The role of T helper (TH)17 cells as a double-edged sword in the interplay of infection and autoimmunity with a focus on xenobiotic-induced immunomodulation.Clinical & developmental immunology · 2013Review
- Interleukin-17 contributes to cardiovascular diseases.Molecular biology reports · 2012Review
- Estrogen deficiency induces the differentiation of IL-17 secreting Th17 cells: a new candidate in the pathogenesis of osteoporosis.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis, a disease characterized by low bone mass and deterioration of bone tissue, is a pressing public health problem. Recent studies have suggested a possible role of T-helper (Th) cells in the pathogenesis of bone loss which occurs in systemic inflammatory diseases. However, there are contradictions in the published literature regarding the functional role of Th1/Th2 cells in the regulation of the differentiation of osteoclasts. These paradoxes have now been clarified by the recent discovery of Th17 cells, a novel subset of Th cells that selectively secrete several proinflammatory cytokines, mainly IL-17. It has been confirmed that Th17 cells have stimulatory effects on osteoclastogenesis and accelerate bone loss in animal models with inflammatory disorders. Targeting Th17 cells or IL-17 may inhibit the bone resorption with RA. Thus, we are led to suppose that Th17 cells might be promising therapeutic targets in osteoporosis.
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Registered trials
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