Evidence map›Paper›PMID 21556686›Full record

ArticleParasitology research2011

Efficacy of ginkgolic acids against Cryptosporidium andersoni in cell culture.

Liang Wu, Xu-gan Jiang, Yu-juan Shen, Zhao-xi Lu, Guo-hua Tu, Xing-li Fu, Sheng-xia Chen, Jian-ping Cao

Abstract read
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In one paragraph

Article in Parasitology research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. In vitro molecular assessment ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Article
  2. Article
  3. Natural Compounds from the Marine Brown AlgaPathogens (Basel, Switzerland) · 2020
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Liang WuSchool of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, 212013, People's Republic of China.
Xu-gan Jiang
Yu-juan Shen
Zhao-xi Lu
Guo-hua Tu
Xing-li Fu
Sheng-xia Chen
Jian-ping Cao
Jiangsu University · CNNational Institute for Parasitic Diseases · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryptosporidium is a worldwide waterborne parasite and the treatment is a severe problem in immunocompromised patients. In this study, we used the in vitro culture system to evaluate the anti-Cryptosporidium activity of ginkgolic acids (GAs), nitazoxanide (NTZ), garlicin (GAR), and artemether (ART). The growth of Cryptosporidium andersoni in HCT-8 cells was determined by real-time PCR assay. When exposed to 5.00 μg/ml GAs or 10.00 μg/ml NTZ for 48 h, the number of C. andersoni in cultures was on a very low lever, but the number of parasites did not significantly decrease when exposed to GAR and ART. Our results indicate that GAs could be a potential drug for the treatment of cryptosporidiosis.

Indexed as

Allyl CompoundsAntiprotozoal AgentsArtemetherArtemisininsCell LineCell SurvivalCryptosporidiumDisulfidesHumansNitro CompoundsParasitic Sensitivity TestsSalicylatesThiazolesAllyl CompoundsAntiprotozoal AgentsArtemetherArtemisininsdiallyl disulfideDisulfidesginkgolic acidnitazoxanideNitro CompoundsSalicylatesThiazoles

Identifiers

PMID21556686
OpenAlexW2005366444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.