ArticlePloS one2011
Tag SNP polymorphism of CCL2 and its role in clinical tuberculosis in Han Chinese pediatric population.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- The association between the monocyte Chemoattractant protein-1-2518A/G polymorphism and the risk of tuberculosis in the Chinese population: A meta-analysis and systematic review.Clinics (Sao Paulo, Brazil) · 2025Pooled it
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- Host Genetic Impact on Infectious Diseases among Different Ethnic Groups.Advanced genetics (Hoboken, N.J.) · 2023Review
- Recent advances in understanding the human host immune response in tuberculous meningitis.Frontiers in immunology · 2023Review
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- Exploring the Role of C-C Motif Chemokine Ligand-2 Single Nucleotide Polymorphism in Pulmonary Tuberculosis: A Genetic Association Study from North India.Journal of immunology research · 2020Article
- Significance of CCL2, CCL5 and CCR2 polymorphisms for adverse prognosis of Japanese encephalitis from an endemic population of India.Scientific reports · 2017Article
- Association betweenInternational journal of clinical and experimental pathology · 2017Article
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- Association of genetic variants in Wnt signaling pathway with tuberculosis in Chinese Han population.PloS one · 2014Article
- HGV&TB: a comprehensive online resource on human genes and genetic variants associated with tuberculosis.Database : the journal of biological databases and curation · 2014Article
- Host gene-encoded severe lung TB: from genes to the potential pathways.Genes and immunity · 2012Article
- Association of LMP/TAP gene polymorphisms with tuberculosis susceptibility in Li population in China.PloS one · 2012Article
- Single nucleotide polymorphisms in MCP-1 and its receptor are associated with the risk of age related macular degeneration.PloS one · 2012Article
- The rs1024611 regulatory region polymorphism is associated with CCL2 allelic expression imbalance.PloS one · 2012Article
- Article
- Host genetics and tuberculosis: Theory of genetic polymorphism and tuberculosis.Lung India : official organ of Indian Chest SocietyArticle
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChemokine (C-C motif) ligand 2 CCL2/MCP-1 is among the key signaling molecules of innate immunity; in particular, it is involved in recruitment of mononuclear and other cells in response to infection, including tuberculosis (TB) and is essential for granuloma formation. METHODOLOGY/PRINCIPAL
findingsWe identified a tag SNP for the CCL2/MCP-1 gene (rs4586 C/T). In order to understand whether this SNP may serve to evaluate the contribution of the CCL2 gene to the expression of TB disease, we further analysed distribution of its alleles and genotypes in 301 TB cases versus 338 non-infected controls (all BCG vaccinated) representing a high-risk pediatric population of North China. In the male TB subgroup, the C allele was identified in a higher rate (P = 0.045), and, acting dominantly, was found to be a risk factor for clinical TB (P = 0.029). Homozygous TT genotype was significantly associated with lower CSF mononuclear leukocyte (ML) counts in patients with tuberculous meningitis (TBM) (P = 0.001). CONCLUSIONS/SIGNIFICANCE: The present study found an association of the CCL2 tag SNP rs4586 C allele and pediatric TB disease in males, suggesting that gender may affect the susceptibility to TB even in children. The association of homozygous TT genotype with decreased CSF mononuclear leukocyte (ML) count not only suggests a clinical significance of this SNP, but indicates its potential to assist in the clinical assessment of suspected TBM, where delay is critical and diagnosis is difficult.
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