ArticleInternational journal of general medicine2011
Pleiotropic effects of the HMG-CoA reductase inhibitors.
Article in International journal of general medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Effect of statin therapy on the progression of coronary atherosclerosis.BMC cardiovascular disorders · 2012Pooled it
- Exploring topical atorvastatin hyalurosomal gel as an adjuvant for reducing systemic corticosteroid dosage: a randomized clinical trial in severe oral lichen planus patients.Drug delivery and translational research · 2026Trial
- Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance.Experimental & molecular medicine · 2025Article
- Trends in statin prescription among osteoporosis patients: A retrospective cohort study using UK primary care data.PLOS global public health · 2025Article
- Exploring the Synergistic Effect of Simvastatin in Oral Health Applications: A Literature Review.Cureus · 2023Review
- The effects of statins on dental and oral health: a review of preclinical and clinical studies.Journal of translational medicine · 2020Review
- Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters.Scientific reports · 2018Article
- Autocrine secretion of 15d-PGJ2 mediates simvastatin-induced apoptotic burst in human metastatic melanoma cells.British journal of pharmacology · 2014Article
- The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in renal disease.International journal of nephrology and renovascular disease · 2014Review
- Regulation of cerebral cholesterol metabolism in Alzheimer disease.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2012Review
- Macrophages, dendritic cells, and regression of atherosclerosis.Frontiers in physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These secondary actions are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropy of statins and emphasizes the importance of randomized placebo-controlled trials to further elucidate this interesting phenomenon.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.