Evidence map›Paper›PMID 21556286›Full record

ArticleThe international journal of biostatistics2011

A complete graphical criterion for the adjustment formula in mediation analysis.

Ilya Shpitser, Tyler J VanderWeele

Abstract read
In one paragraph

Article in The international journal of biostatistics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. Genetic nurturing, missing heritability, and causal analysis in genetic statistics.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  7. Article
  8. Mediation analysis with time varying exposures and mediators.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2017
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The causal mediation formula--a guide to the assessment of pathways and mechanisms.Prevention science : the official journal of the Society for Prevention Research · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ilya ShpitserHarvard University, USA.
Tyler J VanderWeele

Funding

Bounds for direct and indirect effects with application to perinatal epidemiologyR03HD060696 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI VANDERWEELE, TYLER · 2010 to 2011
$169k
NICHD NIH HHS HD060696NICHD NIH HHS R03 HD060696
6 · The paper itself

Abstract

Various assumptions have been used in the literature to identify natural direct and indirect effects in mediation analysis. These effects are of interest because they allow for effect decomposition of a total effect into a direct and indirect effect even in the presence of interactions or non-linear models. In this paper, we consider the relation and interpretation of various identification assumptions in terms of causal diagrams interpreted as a set of non-parametric structural equations. We show that for such causal diagrams, two sets of assumptions for identification that have been described in the literature are in fact equivalent in the sense that if either set of assumptions holds for all models inducing a particular causal diagram, then the other set of assumptions will also hold for all models inducing that diagram. We moreover build on prior work concerning a complete graphical identification criterion for covariate adjustment for total effects to provide a complete graphical criterion for using covariate adjustment to identify natural direct and indirect effects. Finally, we show that this criterion is equivalent to the two sets of independence assumptions used previously for mediation analysis.

Indexed as

Models, StatisticalTreatment OutcomeNegotiatingNonlinear DynamicsStatistics as Topicadjustmentcausal diagramsconfoundingcovariate adjustmentmediationnatural direct and indirect effects

Identifiers

PMID21556286
PMCPMC3083137

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.