ArticleFrontiers in psychiatry2011
Association between 5-HTTLPR and Borderline Personality Disorder Traits among Youth.
Article in Frontiers in psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Borderline personality: revisiting its classification as a neurodevelopmental disorder.Frontiers in psychiatry · 2025Review
- Etiopathogenesis in the Development of Borderline Personality Characteristics in Children and Adolescents.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2024Review
- Please Don't Leave Me-Separation Anxiety and Related Traits in Borderline Personality Disorder.Current psychiatry reports · 2018Review
- Associations of serotonin transporter gene promoter polymorphisms and monoamine oxidase A gene polymorphisms with oppositional defiant disorder in a Chinese Han population.Behavioral and brain functions : BBF · 2018Article
- The 5-HTTLPR genotype, early life adversity and cortisol responsivity to psychosocial stress in women.BJPsych open · 2018Article
- ESCAP Expert Article: borderline personality disorder in adolescence: an expert research review with implications for clinical practice.European child & adolescent psychiatry · 2015Review
- Recent advances in the developmental aspects of borderline personality disorder.Current psychiatry reports · 2015Review
- Review of the genetic basis of emotion dysregulation in children and adolescents.World journal of psychiatry · 2015Review
- 5-HTTLPR × interpersonal stress interaction and nonsuicidal self-injury in general community sample of youth.Psychiatry research · 2015Article
- Serotonin transporter genotype (5-HTTLPR) and electrocortical responses indicating the sensitivity to negative emotional cues.Emotion (Washington, D.C.) · 2013Article
- The Neurobiological Basis of Adolescent-onset Borderline Personality Disorder.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2013Article
- Developmental pathways to borderline personality disorder.Current psychiatry reports · 2012Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
This study provides the first genetic association examination of borderline personality disorder (BPD) traits in children and adolescents (ages 9-15) using two independent samples of youth recruited from the general community. We tested the a priori hypothesis that the serotonin transporter promoter gene (5-HTTLPR) would relate specifically to BPD traits in youth. This association was hypothesized based on prior genetic association research with BPD adults and theory positing that emotion dysregulation may be a core risk process contributing to BPD. Youth provided DNA via buccal cells. Both youth and a parent completed self-report measures assessing youth's BPD traits and depressive symptoms. Results from both Study 1 (N = 242) and an independent replication sample of Study 2 (N = 144) showed that carriers of the short allele of 5-HTTLPR exhibited the highest levels of BPD traits. This relation was observed even after controlling for the substantial co-occurrence between BPD traits and depressive symptoms. This specific association between 5-HTTLPR and BPD traits among youth supports previous genetic associations with adults diagnosed with BPD and provides preliminary support for a developmental extension of etiological risk for BPD among youth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.