ReviewNature reviews. Genetics2011
Understanding systems-level properties: timely stories from the study of clocks.
Review in Nature reviews. Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mining for novel candidate clock genes in the circadian regulatory network.BMC systems biology · 2015Pooled it
- Conserved function of a RasGEF-mediated pathway in the metabolic compensation of the circadian clock.The FEBS journal · 2025Article
- Temperature compensation through kinetic regulation in biochemical oscillators.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Spherical Rotation Dimension Reduction with Geometric Loss Functions.Journal of machine learning research : JMLR · 2024Article
- Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice.Neoplasia (New York, N.Y.) · 2023Article
- Antisense Transcription of theJournal of biological rhythms · 2023Article
- Article
- The Circadian Clocks, Oscillations of Pain-Related Mediators, and Pain.Cellular and molecular neurobiology · 2023Review
- NF-kB in Signaling Patterns and Its Temporal Dynamics Encode/Decode Human Diseases.Life (Basel, Switzerland) · 2022Review
- Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms.Gastroenterology · 2022Article
- Gene networks under circadian control exhibit diurnal organization in primate organs.Communications biology · 2022Article
- Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Defining circadian disruption in neurodegenerative disorders.The Journal of clinical investigation · 2021Review
- Are There Biomimetic Lessons from Genetic Regulatory Networks for Developing a Lunar Industrial Ecology?Biomimetics (Basel, Switzerland) · 2021Review
- A model explaining mRNA level fluctuations based on activity demands and RNA age.PLoS computational biology · 2021Article
- Circadian rhythms in septic shock patients.Annals of intensive care · 2021Article
- Systems Level Understanding of Circadian Integration with Cell Physiology.Journal of molecular biology · 2020Review
- A mobile ELF4 delivers circadian temperature information from shoots to roots.Nature plants · 2020Article
- Role of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis.Molecular and cellular endocrinology · 2020Review
- Circadian Rhythm Disruption Aggravates DSS-Induced Colitis in Mice with Fecal Calprotectin as a Marker of Colitis Severity.Digestive diseases and sciences · 2019Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
After several decades dominated by reductionist approaches in biology, researchers are returning to the study of complex biology with a litany of new and old techniques--this paradigm has been termed systems biology. Here we detail how systems biology is being used to uncover complex systems-level properties of the circadian clock. These properties include robustness, periodicity and temperature compensation. We describe how clock researchers are using systems-biology techniques, such as genetic perturbations, kinetic luminescence imaging, synthetic biology and mathematical modelling, to untangle these complex properties in mammals, fungi and bacteria. The strategies developed in the context of circadian clocks may prove useful for tackling similar problems in other systems.
Indexed as
Identifiers
21556016What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.