ArticleCells, tissues, organs2011
DMP1 and DSPP: evidence for duplication and convergent evolution of two SIBLING proteins.
Article in Cells, tissues, organs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Splicing mutation in DSPP causes dentinogenesis imperfecta and amelogenesis imperfecta.BMC oral health · 2026Article
- Pseudogenes document protracted parallel regression of oral anatomy in myrmecophagous mammals.Molecular biology and evolution · 2026Article
- Functions of secretory calcium-binding phosphoproteins in dental mineralization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Review
- DSP and DPP are dispensable for initiation of dentin and enamel mineralization but critical for circumpulpal dentin mineralization.Scientific reports · 2025Article
- Bank vole genomics links determinate and indeterminate growth of teeth.BMC genomics · 2024Article
- Vole genomics links determinate and indeterminate growth of teeth.bioRxiv : the preprint server for biology · 2024Article
- Odontogenic Effect of Icariin on the Human Dental Pulp Cells.Medicina (Kaunas, Lithuania) · 2022Article
- Inactivation of PI3K/Akt promotes the odontoblastic differentiation and suppresses the stemness with autophagic flux in dental pulp cells.Journal of dental sciences · 2022Article
- The Role of DMP1 in CKD-MBD.Current osteoporosis reports · 2021Review
- Metformin Enhances the Differentiation of Dental Pulp Cells into Odontoblasts by Activating AMPK Signaling.Journal of endodontics · 2018Article
- Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries.Journal of human genetics · 2017Article
- Cancer Secretome May Influence BSP and DSP Expression in Human Salivary Gland Cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Alcohol Inhibits Odontogenic Differentiation of Human Dental Pulp Cells by Activating mTOR Signaling.Stem cells international · 2017Article
- DSPP contains an IRES element responsible for the translation of dentin phosphophoryn.Journal of dental research · 2014Article
- Biomimetic remineralization of dentin.Dental materials : official publication of the Academy of Dental Materials · 2014Article
- Dentin sialophosphoprotein and dentin matrix protein-1: Two highly phosphorylated proteins in mineralized tissues.Archives of oral biology · 2012Review
- Rough endoplasmic reticulum trafficking errors by different classes of mutant dentin sialophosphoprotein (DSPP) cause dominant negative effects in both dentinogenesis imperfecta and dentin dysplasia by entrapping normal DSPP.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
- Adaptive evolution of the matrix extracellular phosphoglycoprotein in mammals.BMC evolutionary biology · 2011Article
- Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice.Matrix biology : journal of the International Society for Matrix BiologyArticle
- Intrinsically disordered proteins and biomineralization.Matrix biology : journal of the International Society for Matrix BiologyReview
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Since first being proposed as a tandem gene family in 2001, the relatedness of the 5 SIBLING proteins (BSP, DMP1, DSPP, MEPE, and SPP1/OPN) has predominantly depended on arguments involving shared intron/exon properties as well as conserved protein biochemical properties (e.g. unstructured and acidic) and specific peptide motifs (e.g. phosphorylation and integrin-binding RGD). This report discusses the evidence that an ancient DMP1 gene underwent a simple duplication in the common ancestor of mammals and reptiles and then separately evolved into DSPP-like paralogs in the 2 classes. Genomic sequence analyses show that different copies of the original DMP1 duplication process were selected by mammalian and reptilian (anole lizard) classes to acquire genetically different but biochemically similar phosphoserine-rich repeat domains by convergent evolution. Mammals, for example, expanded phosphoserine motifs encoded exclusively using motifs containing AGC/T serine codons while the reptile line's repeats also used TCN-encoding serine codons. A similar analysis of the origins of the other 4 SIBLINGs will require even more detailed analysis as genome sequences of various fish and amphibia become available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.