ArticleAntimicrobial agents and chemotherapy2011
Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 82 citations in OpenAlex.
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- Antimicrobial susceptibility of U.S. porcineJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- First molecular detection ofJournal of veterinary research · 2023Article
- Predictive Power of Long-Read Whole-Genome Sequencing for Rapid Diagnostics of Multidrug-Resistant Brachyspira hyodysenteriae Strains.Microbiology spectrum · 2023Article
- Article
- In vitro evaluation of gentamicin activity against Spanish field isolates of Brachyspira hyodysenteriae.Porcine health management · 2022Article
- Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistantEFSA journal. European Food Safety Authority · 2022Article
- Whole-genome analyses reveal a novel prophage and cgSNPs-derived sublineages of Brachyspira hyodysenteriae ST196.BMC genomics · 2022Article
- Dual Antimicrobial Effect of Medium-Chain Fatty Acids against an Italian Multidrug ResistantMicroorganisms · 2022Article
- Combined in-vitro and on-farm evaluation of commercial disinfectants used against Brachyspira hyodysenteriae.Porcine health management · 2022Article
- Assessment of animal diseases caused by bacteria resistant to antimicrobials: Swine.EFSA journal. European Food Safety Authority · 2021Article
- Whole-Genome Sequencing ofFrontiers in microbiology · 2021Article
- Evaluation of a zinc chelate on clinical swine dysentery under field conditions.Porcine health management · 2020Article
- Antimicrobial Resistance inMicrobiology spectrum · 2020Review
- Implementation and evaluation of different eradication strategies forPorcine health management · 2020Article
- TheAntimicrobial agents and chemotherapy · 2019Article
- Role of Sialic Acid in Brachyspira hyodysenteriae Adhesion to Pig Colonic Mucins.Infection and immunity · 2019Article
- Identification of a New Antimicrobial Resistance Gene Provides Fresh Insights Into Pleuromutilin Resistance inFrontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antimicrobial susceptibility of clinical isolates of Brachyspira hyodysenteriae in Spain was monitored, and the underlying molecular mechanisms of resistance were investigated. MICs of tylosin, tiamulin, valnemulin, lincomycin, and tylvalosin were determined for 87 B. hyodysenteriae isolates recovered from 2008 to 2009 by broth dilution. Domain V of the 23S rRNA gene and the ribosomal protein L3 gene were sequenced in 20 isolates for which the tiamulin MIC was ≥ 4 μg/ml, presenting decreased susceptibility, and in 18 tiamulin-susceptible isolates (MIC ≤ 0.125 μg/ml), and all isolates were typed by multiple-locus variable-number tandem repeats analysis. A comparison with antimicrobial susceptibility data from 2000 to 2007 showed an increase in pleuromutilin resistance over time, doubling the number of isolates with decreased susceptibility to tiamulin. No alteration in susceptibility was detected for lincomycin, and the MIC of tylosin remained high (MIC(50) > 128 μg/ml). The decreased susceptibility to tylosin and lincomycin can be explained by mutations at position A2058 of the 23S rRNA gene (Escherichia coli numbering). A2058T was the predominant mutation, but A2058G also was found together with a change of the neighboring base pair at positions 2057 to 2611. The role of additional point mutations in the vicinity of the peptidyl transferase center and mutations in the L3 at amino acids 148 and 149 and their possible involvement in antimicrobial susceptibility are considered. An association between G2032A and high levels of tiamulin and lincomycin MICs was found, suggesting an increasing importance of this mutation in antimicrobial resistance of clinical isolates of B. hyodysenteriae.
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