Trial reportArchives of neurology2011
Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials.
Trial report in Archives of neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- Diet-Induced Weight Loss Alters Functional Brain Responses during an Episodic Memory Task.Obesity facts · 2015Trial
- Tracking cognitive change over 24 weeks with longitudinal functional magnetic resonance imaging in Alzheimer's disease.Neuro-degenerative diseases · 2012Trial
- Reliability of brain metrics derived from a Time-Domain Functional Near-Infrared Spectroscopy System.Scientific reports · 2024Article
- Test-retest reliability of the "Home Town Walk" fMRI paradigm for memory activation and lateralization in the pre-surgical evaluation of patients with temporal lobe epilepsy.Frontiers in neurology · 2024Article
- fMRI Investigation of Semantic Lexical Processing in Healthy Control and Alzheimer's Disease Subjects Using Naming Task: A Preliminary Study.Brain sciences · 2021Article
- Hippocampal activation and connectivity in the aging brain.Brain imaging and behavior · 2021Article
- Test-retest reliability of brain responses to risk-taking during the balloon analogue risk task.NeuroImage · 2020Article
- Test-retest reliability of spatial navigation in adults at-risk of Alzheimer's disease.PloS one · 2020Article
- Application of calibrated fMRI in Alzheimer's disease.NeuroImage. Clinical · 2017Article
- Brain imaging of neurovascular dysfunction in Alzheimer's disease.Acta neuropathologica · 2016Review
- Memory network plasticity after temporal lobe resection: a longitudinal functional imaging study.Brain : a journal of neurology · 2016Article
- Bringing memory fMRI to the clinic: comparison of seven memory fMRI protocols in temporal lobe epilepsy.Human brain mapping · 2015Article
- Flexible modulation of network connectivity related to cognition in Alzheimer's disease.NeuroImage · 2014Article
- Intersession reliability of fMRI activation for heat pain and motor tasks.NeuroImage. Clinical · 2014Article
- Imaging as a biomarker in drug discovery for Alzheimer's disease: is MRI a suitable technology?Alzheimer's research & therapy · 2014Review
- Reliability measures of functional magnetic resonance imaging in a longitudinal evaluation of mild cognitive impairment.NeuroImage · 2014Article
- DICCCOL: dense individualized and common connectivity-based cortical landmarks.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- Fusiform correlates of facial memory in autism.Behavioral sciences (Basel, Switzerland) · 2013Article
- Test-Retest Reliability of fMRI Brain Activity during Memory Encoding.Frontiers in psychiatry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo examine the feasibility and test-retest reliability of encoding-task functional magnetic resonance imaging (fMRI) in mild Alzheimer disease (AD).
designRandomized, double-blind, placebo-controlled study.
settingMemory clinical trials unit.
participantsWe studied 12 patients with mild AD (mean [SEM] Mini-Mental State Examination score, 24.0 [0.7]; mean Clinical Dementia Rating score, 1.0) who had been taking donepezil hydrochloride for more than 6 months from the placebo arm of a larger 24-week study (n = 24, 4 scans on weeks 0, 6, 12, and 24, respectively).
interventionsPlacebo and 3 face-name, paired-associate encoding, block-design blood oxygenation level-dependent fMRI scans in 12 weeks.
main outcome measuresWe performed whole-brain t maps (P < .001, 5 contiguous voxels) and hippocampal regions-of-interest analyses of extent (percentage of active voxels) and magnitude (percentage of signal change) for novel-greater-than-repeated face-name contrasts. We also calculated intraclass correlation coefficients and power estimates for hippocampal regions of interest.
resultsTask tolerability and data yield were high (95 of 96 scans yielded favorable-quality data). Whole-brain maps were stable. Right and left hippocampal regions-of-interest intraclass correlation coefficients were 0.59 to 0.87 and 0.67 to 0.74, respectively. To detect 25.0% to 50.0% changes in week-0 to week-12 hippocampal activity using left-right extent or right magnitude with 80.0% power (2-sided α = .05) requires 14 to 51 patients. Using left magnitude requires 125 patients because of relatively small signal to variance ratios.
conclusionsEncoding-task fMRI was successfully implemented in a single-site, 24-week, AD randomized controlled trial. Week 0 to 12 whole-brain t maps were stable, and test-retest reliability of hippocampal fMRI measures ranged from moderate to substantial. Right hippocampal magnitude may be the most promising of these candidate measures in a leveraged context. These initial estimates of test-retest reliability and power justify evaluation of encoding-task fMRI as a potential biomarker for signal of effect in exploratory and proof-of-concept trials in mild AD. Validation of these results with larger sample sizes and assessment in multisite studies is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.