ArticleProceedings of the National Academy of Sciences of the United States of America2011
N-acetylserotonin promotes hippocampal neuroprogenitor cell proliferation in sleep-deprived mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- Partners in health and disease: pineal gland and purinergic signalling.Purinergic signalling · 2025Review
- LncRNA-MSTRG.19083.1 Targets NTRK2 as a miR-429-y Sponge to Regulate Circadian Rhythm via the cAMP Pathway in Yak Testis and Cryptorchidism.International journal of molecular sciences · 2024Article
- Brain Specific RagA Overexpression Triggers Depressive-Like Behaviors in Mice via Activating ADORA2A Signaling Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Parallel pathways for serotonin biosynthesis and metabolism in C. elegans.Nature chemical biology · 2023Article
- The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature.BMC cancer · 2022Review
- A Tropomycin-Related Kinase B Receptor Activator for the Management of Ocular Blast-Induced Vision Loss.Journal of neurotrauma · 2021Article
- The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms.International journal of molecular sciences · 2020Review
- Neuromodulation of the Pineal Gland via Electrical Stimulation of Its Sympathetic Innervation Pathway.Frontiers in neuroscience · 2020Review
- Blood platelet research in autism spectrum disorders: In search of biomarkers.Research and practice in thrombosis and haemostasis · 2019Review
- Dexmedetomidine ameliorates memory impairment in sleep-deprived mice.Animal cells and systems · 2019Article
- Heritability of the melatonin synthesis variability in autism spectrum disorders.Scientific reports · 2017Article
- Protective roles of melatonin in central nervous system diseases by regulation of neural stem cells.Cell proliferation · 2017Review
- Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway.The Journal of biological chemistry · 2016Article
- Comparison of melatonin with growth factors in promoting precursor cells proliferation in adult mouse subventricular zone.EXCLI journal · 2016Article
- Neuroprotective role of an N-acetyl serotonin derivative via activation of tropomyosin-related kinase receptor B after subarachnoid hemorrhage in a rat model.Neurobiology of disease · 2015Article
- The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders.Translational psychiatry · 2014Article
- A time to remember: the role of circadian clocks in learning and memory.Behavioral neuroscience · 2014Review
- Protective effect of N-acetylserotonin against acute hepatic ischemia-reperfusion injury in mice.International journal of molecular sciences · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
N-acetylserotonin (NAS), the immediate precursor of melatonin, the pineal gland indole, is regulated in a circadian rhythm. NAS swiftly activates TrkB in a circadian manner and exhibits antidepressant effect in a TrkB-dependent manner. Here we show that NAS regulates an early event of neurogenesis by increasing neuronal progenitor cell (NPC) proliferation. Subchronic and chronic NAS administration induces NPC proliferation in adult mice. Chronic NAS treatment triggers TrkB receptor activation and its downstream signaling in NPCs. Blockade of TrkB abolishes NAS-elicited neurogenesis in TrkBF616A knockin mice, suggesting that TrkB activation is essential for the effect of NAS-induced NPC proliferation. Moreover, NAS induces NPC proliferation in both active and sleeping phases of the mice. Strikingly, NAS significantly enhances NPC proliferation in sleep-deprived mice. Thus, our finding demonstrates a unique function of NAS in promoting robust NPC proliferation, which may contribute to hippocampal plasticity during sleeping period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.