ArticleProceedings of the National Academy of Sciences of the United States of America2011
Optogenetic-guided cortical plasticity after nerve injury.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 67 citations in OpenAlex.
- Crosstalk Between Cortical Plasticity and Peripheral Nervous Injury: Insights, Mechanisms, and Future Directions.CNS neuroscience & therapeutics · 2026Review
- Multimodal MRI links gray matter volume loss and temporal lobe susceptibility to CSF immunological profiles in Guillain-Barré syndrome.Frontiers in immunology · 2026Article
- Reactivated thalamocortical plasticity alters neural activity in sensory-motor cortex during post-critical period.Progress in neurobiology · 2025Article
- Charting the path in rodent functional neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cortical Reorganization after Limb Loss: Bridging the Gap between Basic Science and Clinical Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Magnetogenetic stimulation inside MRI induces spontaneous and evoked changes in neural circuits activity in rats.Frontiers in neuroscience · 2024Article
- Magnetogenetic stimulation inside MRI induces spontaneous and evoked changes in neural circuits activity in rats.bioRxiv : the preprint server for biology · 2023Article
- Peripheral Nerve Injury Induces Changes in the Activity of Inhibitory Interneurons as Visualized in Transgenic GAD1-GCaMP6s Rats.Biosensors · 2022Article
- fNIRS brain measures of ongoing nociception during surgical incisions under anesthesia.Neurophotonics · 2022Article
- Establishing an Octopus Ecosystem for Biomedical and Bioengineering Research.Journal of visualized experiments : JoVE · 2021Article
- Interhemispheric transfer of post-amputation cortical plasticity within the human somatosensory cortex.NeuroImage · 2020Article
- Enhancing plasticity in central networks improves motor and sensory recovery after nerve damage.Nature communications · 2019Article
- Potential Application of Optogenetic Stimulation in the Treatment of Pain and Migraine Headache: A Perspective from Animal Studies.Brain sciences · 2019Review
- Multimodal Evaluation of TMS - Induced Somatosensory Plasticity and Behavioral Recovery in Rats With Contusion Spinal Cord Injury.Frontiers in neuroscience · 2019Article
- Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields.Scientific reports · 2018Article
- Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal.NeuroImage · 2017Review
- Altered microstructure rather than morphology in the corpus callosum after lower limb amputation.Scientific reports · 2017Article
- Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks.Nature communications · 2017Article
- Novel Neuromodulation Techniques to Assess Interhemispheric Communication in Neural Injury and Neurodegenerative Diseases.Frontiers in neural circuits · 2017Review
- Role of Neuromodulation and Optogenetic Manipulation in Pain Treatment.Current neuropharmacology · 2016Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Peripheral nerve injury causes sensory dysfunctions that are thought to be attributable to changes in neuronal activity occurring in somatosensory cortices both contralateral and ipsilateral to the injury. Recent studies suggest that distorted functional response observed in deprived primary somatosensory cortex (S1) may be the result of an increase in inhibitory interneuron activity and is mediated by the transcallosal pathway. The goal of this study was to develop a strategy to manipulate and control the transcallosal activity to facilitate appropriate plasticity by guiding the cortical reorganization in a rat model of sensory deprivation. Since transcallosal fibers originate mainly from excitatory pyramidal neurons somata situated in laminae III and V, the excitatory neurons in rat S1 were engineered to express halorhodopsin, a light-sensitive chloride pump that triggers neuronal hyperpolarization. Results from electrophysiology, optical imaging, and functional MRI measurements are concordant with that within the deprived S1, activity in response to intact forepaw electrical stimulation was significantly increased by concurrent illumination of halorhodopsin over the healthy S1. Optogenetic manipulations effectively decreased the adverse inhibition of deprived cortex and revealed the major contribution of the transcallosal projections, showing interhemispheric neuroplasticity and thus, setting a foundation to develop improved rehabilitation strategies to restore cortical functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.