ArticleProceedings of the National Academy of Sciences of the United States of America2011
B cells within germinal centers migrate preferentially from dark to light zone.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- BLIMP1 shapes germinal center B cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition.Nature immunology · 2026Article
- Diffusion-limited cytokine signaling in T cell populations.iScience · 2024Article
- A multiscale spatial modeling framework for the germinal center response.Frontiers in immunology · 2024Article
- Single-cell spatial metabolomics with cell-type specific protein profiling for tissue systems biology.Nature communications · 2023Article
- Compartments and Connections Within the Germinal Center.Frontiers in immunology · 2021Review
- A New Method Based on the von Mises-Fisher Distribution Shows that a Minority of Liver-Localized CD8 T Cells Display Hard-To-Detect Attraction toFrontiers in bioinformatics · 2021Article
- Article
- Cell Cycle-Associated CXCR4 Expression in Germinal Center B Cells and Its Implications on Affinity Maturation.Frontiers in immunology · 2018Article
- Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Dendritic cells: key players in human herpesvirus 8 infection and pathogenesis.Frontiers in microbiology · 2014Review
- IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- B-lymphocyte lineage cells and the respiratory system.The Journal of allergy and clinical immunology · 2013Review
- A one-shot germinal center model under protein structural stability constraints.Physical biology · 2013Article
- Automated characterization and parameter-free classification of cell tracks based on local migration behavior.PloS one · 2013Article
- Expression of N-cadherin in salivary gland tumors.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2013Article
- A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields.Bulletin of mathematical biology · 2013Article
- Analytical results on the Beauchemin model of lymphocyte migration.BMC bioinformatics · 2013Article
- S1PR2 links germinal center confinement and growth regulation.Immunological reviews · 2012Review
- Understanding natural killer cell regulation by mathematical approaches.Frontiers in immunology · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
One of the main questions in the field of imaging immune cell migration in living tissues is whether cells fulfill their functionality via random or nonrandom migration processes. For some applications, this issue has remained controversial even after publication of various imaging studies. A prime example is B-cell migration in germinal centers (GCs) where somatic hypermutation and clonal selection of B cells are thought to occur within morphologically distinct regions termed dark zone (DZ) and light zone (LZ). Here, we reanalyze a previously published dataset on GC B-cell migration, applying a sensitive analysis technique to detect directed migration and using a procedure to correct for a number of artifacts that frequently occur in time-lapse imaging experiments. Although B cells roughly perform a persistent random walk, we present evidence that they have a small preference (of on average about 0.2-0.3 μm min(-1)) to migrate from DZ to LZ, which is consistent with classical views of the GC reaction. This preference is most pronounced among a large subset of almost half of the B-cell population migrating along relatively straight tracks. Using a computational model to generate long-lasting B-cell tracks based on the experimental motility data (including the small directional preference), we predict a time course to travel from DZ to LZ of a few hours. This is consistent with experimental observations, and we show that at the observed cellular motility such a time course cannot be explained without the small preferential migration from DZ to LZ.
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Registered trials
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