Evidence map›Paper›PMID 21555568›Full record

ReviewProceedings of the National Academy of Sciences of the United States of America2011

Quantitative descriptions of generalized arousal, an elementary function of the vertebrate brain.

Amy Wells Quinkert, Vivek Vimal, Zachary M Weil, George N Reeke, Nicholas D Schiff, Jayanth R Banavar, Donald W Pfaff

Open access · greenAbstract readReview
In one paragraph

Review in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Rough is salient: a conserved vocal niche to hijack the brain's salience system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Interoception and drug addiction.Neuropharmacology · 2014
    Review
  11. How pleasant sounds promote and annoying sounds impede health: a cognitive approach.International journal of environmental research and public health · 2013
    Article
  12. Article
  13. Quantification of behavior.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Amy Wells QuinkertLaboratory of Neurobiology and Behavior and Laboratory of Biological Modelling, The Rockefeller University, New York, NY 10065, USA. awells@rockefeller.edu
Vivek Vimal
Zachary M Weil
George N Reeke
Nicholas D Schiff
Jayanth R Banavar
Donald W Pfaff
Institute of Neurobiology · BGCornell University · USPennsylvania State University · USRockefeller University · US

Funding

Brain Mechanisms of Reproductive BehaviorR37HD005751 · NICHD · ROCKEFELLER UNIVERSITY · PI PFAFF, DONALD W. · 2003 to 2012
$3.8M
RETICULOSPINAL &VESTIBULOSPINAL CONTROL OF BACK MUSCLESR01MH038273 · NIMH · ROCKEFELLER UNIVERSITY · PI PFAFF, DONALD W. · 1985 to 2010
$3.6M
CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELSR01NS067249 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUTSON, CHRISTOPHER R, PFAFF, DONALD W. · 2009 to 2013
$3.2M
BRAIN MECHANISMS OF REPRODUCTIVE BEHAVIOR IN RATSR01HD005751 · NICHD · ROCKEFELLER UNIVERSITY · PI PFAFF, DONALD WELLS · 1985 to 2002
$999k
NICHD NIH HHS HD-05751NICHD NIH HHS R01 HD005751NICHD NIH HHS R37 HD005751NIMH NIH HHS MH-38273NIMH NIH HHS R01 MH038273NINDS NIH HHS R01 NS067249
6 · The paper itself

Abstract

We review a concept of the most primitive, fundamental function of the vertebrate CNS, generalized arousal (GA). Three independent lines of evidence indicate the existence of GA: statistical, genetic, and mechanistic. Here we ask, is this concept amenable to quantitative analysis? Answering in the affirmative, four quantitative approaches have proven useful: (i) factor analysis, (ii) information theory, (iii) deterministic chaos, and (iv) application of a Gaussian equation. It strikes us that, to date, not just one but at least four different quantitative approaches seem necessary for describing different aspects of scientific work on GA.

Indexed as

AnimalsArousalBrainHumansHungerInformation TheoryNonlinear DynamicsVertebrates

Identifiers

PMID21555568
PMCPMC3176607
OpenAlexW2077307776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.