ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Donor macrophage depletion permits posttransplant tolerance induction in a murine islet transplant model.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Observational
- Location versus ID: what matters to lung-resident memory T cells?Frontiers in immunology · 2024Article
- Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin.Nature communications · 2023Article
- Microneedle-Mediated Immunization Promotes Lung CD8+ T-Cell Immunity.The Journal of investigative dermatology · 2023Article
- CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8Immunity · 2023Article
- RNAi-based modulation of IFN-γ signaling in skin.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- High Fat Diet-Induced CD8Frontiers in immunology · 2021Article
- Antibody-suppressor CD8+ T Cells Require CXCR5.Transplantation · 2019Article
- Disruption of CXCR3 function impedes the development of Sjögren's syndrome-like xerostomia in non-obese diabetic mice.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Melanoma Induces, and Adenosine Suppresses, CXCR3-Cognate Chemokine Production and T-cell Infiltration of Lungs Bearing Metastatic-like Disease.Cancer immunology research · 2015Article
- Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints.Nature communications · 2015Article
- The integrative roles of chemokines at the maternal-fetal interface in early pregnancy.Cellular & molecular immunology · 2014Review
- CXCR3 modulates obesity-induced visceral adipose inflammation and systemic insulin resistance.Obesity (Silver Spring, Md.) · 2014Article
- Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation.The Journal of allergy and clinical immunology · 2013Article
- ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection.PloS one · 2013Article
- Update on lung transplantation: programmes, patients and prospects.European respiratory review : an official journal of the European Respiratory Society · 2012Review
- Enhanced Tim3 activity improves survival after influenza infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Pulmonary T cell activation in response to chronic particulate air pollution.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Persistence in Temporary Lung Niches: A Survival Strategy of Lung-Resident Memory CD8Viral immunologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Lung transplantation remains the only effective therapy for patients with end-stage pulmonary diseases. Unfortunately, acute rejection of the lung remains a frequent complication and is an important cause of morbidity and mortality. The induction of transplant tolerance is thought to be dependent, in part, on the balance between allograft effector mechanisms mediated by effector T lymphocytes (Teff), and regulatory mechanisms mediated by FOXP3(+) regulatory T cells (Treg). In this study, we explored an approach to tip the balance in favor of regulatory mechanisms by modulating chemokine activity. We demonstrate in an adoptive transfer model of lung rejection that CXCR3-deficient CD8(+) Teff have impaired migration into the lungs compared with wild-type Teff, which results in a dramatic reduction in fatal pulmonary inflammation. The lungs of surviving mice contained tolerized CXCR3-deficient Teff, as well as a large increase in Treg. We confirmed that Treg were needed for tolerance and that their ability to induce tolerance was dependent on their numbers in the lung relative to the numbers of Teff. These data suggest that transplantation tolerance can be achieved by reducing the recruitment of some, but not necessarily all, CD8(+) Teff into the target organ and suggest a novel approach to achieve transplant tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.