Evidence map›Paper›PMID 21555055›Full record

ArticlePediatric neurology2011

Topiramate for the treatment of neonatal seizures.

Hannah C Glass, Chantal Poulin, Michael I Shevell

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
8.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Anti-seizure medications for neonates with seizures.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Continuous electroencephalography in the intensive care unit: A critical review and position statement from an Australian and New Zealand perspective.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2023
    Article
  7. Review
  8. Novel Therapeutics for Neonatal Seizures.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  9. Article
  10. Status Epilepticus in the Neonate: Updates in Treatment Strategies.Current treatment options in neurology · 2019
    Review
  11. Review
  12. Recent Advances in Neonatal Seizures.Current neurology and neuroscience reports · 2016
    Review
  13. Review
  14. Newer antiepileptic drugs: evidence based use.Indian journal of pediatrics · 2014
    Review
  15. Can we safely administer the recommended dose of phenobarbital in very low birth weight infants?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013
    Article
  16. Article
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Hannah C GlassDepartment of Neurology and Department of Pediatrics, University of California at San Francisco, San Francisco, California 94143-0663, USA. Hannah.Glass@ucsf.edu
Chantal Poulin
Michael I Shevell
McGill University Health Centre · CAUniversity of California, San Francisco · US

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
MRI Mechanisms of Adverse Outcome in Preterm Infants with SeizuresK23NS066137 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLASS, HANNAH CRANLEY · 2010 to 2014
$858k
NCRR NIH HHS KL2 RR024130NINDS NIH HHS K23 NS066137NINDS NIH HHS K23NS066137
6 · The paper itself

Abstract

Therapeutic options for treating neonatal seizures, such as phenobarbital and phenytoin, lack efficacy and are potentially harmful to the developing brain. Topiramate appears effective as both an antiseizure and neuroprotective agent in animal models of newborn brain injury. Although topiramate is a common add-on agent in newborns, its use in this population has not yet been reported. We performed a retrospective cohort study of clinical topiramate use in newborns with acute symptomatic seizures that were refractory to standard agents. In four of six newborns, apparent reduction or no further seizures occurred. None of the children experienced side effects resulting in discontinuation of the drug, either during the hospital admission or after discharge. Prospective studies evaluating the safety and efficacy of topiramate for both seizures and neuroprotection will be important in determining whether it deserves widespread use in clinical practice.

Indexed as

Age FactorsCohort StudiesFemaleFollow-Up StudiesFructoseHumansInfant, NewbornMalePatient AdmissionPatient DischargeRetrospective StudiesSeizuresTopiramateTreatment OutcomeFructoseTopiramate

Identifiers

PMID21555055
PMCPMC3092106
OpenAlexW2103487664

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.