ArticleBrain, behavior, and immunity2011
Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease.
Article in Brain, behavior, and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of brain-derived neurotrophic factor genetic polymorphism on cognition: A systematic review.Brain and behavior · 2018Pooled it
- Genetics of serum BDNF: meta-analysis of the Val66Met and genome-wide association study.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2013Pooled it
- Efficacy and safety of N-acetylcysteine in patients with mild cognitive impairment undergoing exercise-based cardiac rehabilitation program: a randomized controlled trial.Alzheimer's research & therapy · 2026Trial
- Ceramides predict verbal memory performance in coronary artery disease patients undertaking exercise: a prospective cohort pilot study.BMC geriatrics · 2013Trial
- Association of Circulating Brain-Derived Neurotrophic Factor With Coronary Risk Factors and Coronary Artery Disease in Patients Who Have Undergone Coronary Computed Tomography Angiography.Cardiology research · 2026Article
- Neurotrophic Factors: Emerging Biology and Therapeutic Applications for Cardiovascular Diseases.Metabolites · 2026Review
- Preliminary results of the cross-sectional associations of sedentary behavior and physical activity with serum brain-derived neurotrophic factor in adults with coronary heart disease.Scientific reports · 2022Article
- An examination of the relationship among plasma brain derived neurotropic factor, peripheral vascular function, and body composition with cognition in midlife African Americans/Black individuals.Frontiers in aging neuroscience · 2022Article
- Brain-Derived Neurotrophic Factor Reduces Long-Term Mortality in Patients With Coronary Artery Disease and Chronic Kidney Disease.Frontiers in cardiovascular medicine · 2022Article
- Sex-Specific Associations of Brain-Derived Neurotrophic Factor and Cardiorespiratory Fitness in the General Population.Biomolecules · 2019Article
- Serum Renalase Levels Are Predicted by Brain-Derived Neurotrophic Factor and Associated with Cardiovascular Events and Mortality after Percutaneous Coronary Intervention.Journal of clinical medicine · 2018Article
- Cognitive function in patients with coronary artery disease: A literature review.The Journal of international medical research · 2018Review
- An acute bout of aerobic or strength exercise specifically modifies circulating exerkine levels and neurocognitive functions in elderly individuals with mild cognitive impairment.NeuroImage. Clinical · 2018Article
- A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise.Journal of Alzheimer's disease : JAD · 2017Article
- Lipid Peroxidation Markers in Coronary Artery Disease Patients with Possible Vascular Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2017Article
- Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in Women.Mediators of inflammation · 2015Article
- Neurocognitive effects of ketamine in treatment-resistant major depression: association with antidepressant response.Psychopharmacology · 2013Article
- Dementia: A link between microbial infection and cognition?Nature reviews. Neurology · 2013Article
- Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging.Mayo Clinic proceedings · 2011Review
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveTo assess serum brain derived neurotrophic factor (BDNF) concentrations as a correlate of cardiopulmonary fitness and as a predictor of cognitive performance in subjects with coronary artery disease (CAD).
methodsSerum BDNF concentrations were assayed by ELISA and fitness was assessed using a standardized exercise stress test. The Mini Mental Status Examination (MMSE), California Verbal Learning Test 2nd Ed., Stroop, Trail Making Test B and the Digit Symbol-Coding task were administered. The val66met BDNF genotype and serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations were determined as potential confounders.
resultsIn subjects with CAD (n=88; 85.2% male, mean age 62.8±10.5 yr), cardiopulmonary fitness was associated with higher serum BDNF concentrations (β=.305, p=.013). Higher serum BDNF concentrations were associated with higher MMSE scores (F(1,87)=15.406, p<.0005) and better performance on the Digit Symbol-Coding task (F(1,87)=9.620, p=.003). IL-6, TNF-α and the val66met genotype did not influence these results.
conclusionSerum BDNF concentrations were associated with cardiopulmonary fitness, psychomotor processing speed and overall cognition in subjects with CAD.
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Registered trials
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