ArticleBMC genomics2011
Probing genomic diversity and evolution of Streptococcus suis serotype 2 by NimbleGen tiling arrays.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Streptococcus suis infection as an emerging zoonotic threat in Brazil: a One Health-based review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Review
- Mechanistic Landscape and Farm to Fork Control Strategies forTransboundary and emerging diseases · 2026Review
- Epidemiological and genomic analyses of human isolates ofFrontiers in microbiology · 2023Article
- Genome analysis provides insight into hyper-virulence of Streptococcus suis LSM178, a human strain with a novel sequence type 1005.Scientific reports · 2021Article
- Article
- The Impact of SsPI-1 Deletion onPathogens (Basel, Switzerland) · 2019Article
- Isolation and characterization of a native avirulent strain of Streptococcus suis serotype 2: a perspective for vaccine development.Scientific reports · 2015Article
- Antimicrobial Resistance Profile and Genotypic Characteristics of Streptococcus suis Capsular Type 2 Isolated from Clinical Carrier Sows and Diseased Pigs in China.BioMed research international · 2015Article
- Population analysis of Streptococcus suis isolates from slaughtered swine by use of minimum core genome sequence typing.Journal of clinical microbiology · 2014Article
- Streptococcus suis infection: an emerging/reemerging challenge of bacterial infectious diseases?Virulence · 2014Review
- Comparative genomic hybridization identifies virulence differences in Streptococcus suis.PloS one · 2014Article
- Type-IVC secretion system: a novel subclass of type IV secretion system (T4SS) common existing in gram-positive genus Streptococcus.PloS one · 2012Article
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur previous studies revealed that a new disease form of streptococcal toxic shock syndrome (STSS) is associated with specific Streptococcus suis serotype 2 (SS2) strains. To achieve a better understanding of the pathogenicity and evolution of SS2 at the whole-genome level, comparative genomic analysis of 18 SS2 strains, selected on the basis of virulence and geographic origin, was performed using NimbleGen tiling arrays.
resultsOur results demonstrate that SS2 isolates have highly divergent genomes. The 89K pathogenicity island (PAI), which has been previously recognized as unique to the Chinese epidemic strains causing STSS, was partially included in some other virulent and avirulent strains. The ABC-type transport systems, encoded by 89K, were hypothesized to greatly contribute to the catastrophic features of STSS. Moreover, we identified many polymorphisms in genes encoding candidate or known virulence factors, such as PlcR, lipase, sortases, the pilus-associated proteins, and the response regulator RevS and CtsR. On the basis of analysis of regions of differences (RDs) across the entire genome for the 18 selected SS2 strains, a model of microevolution for these strains is proposed, which provides clues into Streptococcus pathogenicity and evolution.
conclusionsOur deep comparative genomic analysis of the 89K PAI present in the genome of SS2 strains revealed details into how some virulent strains acquired genes that may contribute to STSS, which may lead to better environmental monitoring of epidemic SS2 strains.
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