ArticleBMC cancer2011
Influence of family size and birth order on risk of cancer: a population-based study.
Article in BMC cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of maternal reproductive factors on cancer risks of offspring: A systematic review and meta-analysis of cohort studies.PloS one · 2020Pooled it
- Assessing the social and physical determinants of circumpolar population health.International journal of circumpolar health · 2013Pooled it
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- Lower birth rate, greater female dementia risk: global and regional patterns and public health implications.Future science OA · 2025Article
- Number of Older Biological Siblings and Early-Onset Colorectal Cancer Risk.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Article
- Risk of prostate cancer in relatives of prostate cancer patients in Sweden: A nationwide cohort study.PLoS medicine · 2021Article
- Familial colorectal cancer risk in half siblings and siblings: nationwide cohort study.BMJ (Clinical research ed.) · 2019Article
- Greater family size is associated with less cancer risk: an ecological analysis of 178 countries.BMC cancer · 2018Article
- Joint Families and Cancer Diagnosis in Rural IndiaAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Childhood cancer incidence by ethnic group in England, 2001-2007: a descriptive epidemiological study.BMC cancer · 2017Article
- Birth order and mortality: a population-based cohort study.Demography · 2015Article
- Season of birth and other perinatal risk factors for melanoma.International journal of epidemiology · 2014Article
- Comparison of address-based sampling and random-digit dialing methods for recruiting young men as controls in a case-control study of testicular cancer susceptibility.American journal of epidemiology · 2013Article
- Birth Rate as a Determinant of Dementia Incidence: A Comprehensive Global Analysis.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFamily size and birth order are known to influence the risk of some cancers. However, it is still unknown whether these effects change from early to later adulthood. We used the data of the Swedish Family-Cancer Database to further analyze these effects.
methodsWe selected over 5.7 million offspring with identified parents but no parental cancer. We estimated the effect of birth order and family size by Poisson regression adjusted for age, sex, period, region and socioeconomic status. We divided the age at diagnosis in two groups, below and over 50 years, to identify the effect of family size and birth order for different age periods.
resultsNegative associations for increasing birth order were found for endometrial, testicular, skin, thyroid and connective tissue cancers and melanoma. In contrast, we observed positive association between birth order and lung, male and female genital cancers. Family size was associated with decreasing risk for endometrial and testicular cancers, melanoma and squamous cell carcinoma; risk was increased for leukemia and nervous system cancer. The effect of birth order decreased for lung and endometrial cancer from age at diagnosis below to over 50 years. Combined effects for birth order and family size were marginally significant for thyroid gland tumors. Especially, the relative risk for follicular thyroid gland tumors was significantly decreased for increasing birth order.
conclusionOur findings suggest that the effect of birth order decreases from early to late adulthood for lung and endometrial cancer.
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