ArticleAddiction biology2012
Dopaminergic genes modulate response inhibition in alcohol abusing adults.
Article in Addiction biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The ICCAM platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part B: fMRI description.Journal of psychopharmacology (Oxford, England) · 2017Pooled it
- Dopaminergic Genetic Variation Influences Aripiprazole Effects on Alcohol Self-Administration and the Neural Response to Alcohol Cues in a Randomized Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- The 7-Repeat (7R) Variant of theInternational journal of molecular sciences · 2025Article
- Association between Polymorphism rs1799732 ofInternational journal of environmental research and public health · 2022Article
- The Molecular Basis of Alcohol Use Disorder (AUD). Genetics, Epigenetics, and Nutrition in AUD: An Amazing Triangle.International journal of molecular sciences · 2021Review
- Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention.Frontiers in psychiatry · 2018Article
- Genetic studies of alcohol dependence in the context of the addiction cycle.Neuropharmacology · 2017Review
- Testing differential susceptibility: Plasticity genes, the social environment, and their interplay in adolescent response inhibition.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2017Article
- An association study ofAnnals of general psychiatry · 2017Article
- fMRI study of neural sensitization to hedonic stimuli in long-term, daily cannabis users.Human brain mapping · 2016Article
- The latent structure of impulsivity: impulsive choice, impulsive action, and impulsive personality traits.Psychopharmacology · 2016Article
- Neuroscience of inhibition for addiction medicine: from prediction of initiation to prediction of relapse.Progress in brain research · 2016Review
- DRD4 and susceptibility to peer influence on alcohol use from adolescence to adulthood.Drug and alcohol dependence · 2014Article
- Preliminary functional MRI results from a combined stop-signal alcohol-cue task.Journal of studies on alcohol and drugs · 2014Article
- Differential reward network functional connectivity in cannabis dependent and non-dependent users.Drug and alcohol dependence · 2014Article
- Potential contribution of dopaminergic gene variants in ADHD core traits and co-morbidity: a study on eastern Indian probands.Cellular and molecular neurobiology · 2014Article
- Behavioral disinhibition in mice bred for high drinking in the dark (HDID) and HS controls increases following ethanol.Drug and alcohol dependence · 2014Article
- Integrating brain and behavior: evaluating adolescents' response to a cannabis intervention.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2013Article
- Fronto-striatal functional connectivity during response inhibition in alcohol dependence.Addiction biology · 2013Article
- Convergent functional genomics in addiction research - a translational approach to study candidate genes and gene networks.In silico pharmacology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have been implicated not only for risk for AUD but also for impulsivity based on behavioral studies, we set out to examine the underlying neural mechanisms associated with these effects. We collected functional magnetic resonance imaging images on 53 heavy drinking but otherwise healthy adults while performing the Go/NoGo task. We predicted that genetic variants previously reported in the literature to be associated with substance abuse, specifically the DRD2 rs1799732 and DRD4 VNTR, will modulate neural processes underlying response inhibition. Our results showed differential neural response for the DRD4 VNTR during successful inhibition in the inferior frontal gyrus (IFG) (cluster-corrected P<0.05, z=1.9). Similarly, DRD2 rs1799732 groups were significantly different in the precuneus and cingulate gyrus during successful response inhibition (cluster-corrected P<0.05, z=1.9). These findings provide further evidence for the role of DAergic genes in modulating neural response in areas that underlie response inhibition and self-monitoring processes. Variants within these genes appear to influence processes related to impulsive behavior, which may increase one's risk for alcohol abuse and dependence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.